Abstract
We mapped the three dimensional (3D) extents and variability of selected sulci in the Alzheimer's brain and explored the relationship between sulcal pattern and patient's cognitive performance. High-resolution MRIs of 10 patients with probable Alzheimer's disease (AD) were linearly transformed into a standard "normalized" 3D atlas (known as the Talairach coordinate system) and, on each relevant slice, contours of the left and right Sylvian fissure, anterior and posterior calcarine, callosal, parietooccipital, and cingulate sulci and the floor of the temporal horn of the lateral ventricle were traced. These landmarks were chosen because of their relative invariant location across individuals and because they demarcate functional boundaries relevant in AD. The sulcal contours were resolved into two-dimensional surfaces that cut through a brain volume. All 10 patients' sulcal surfaces were averaged to determine their mean spatial locations in the Talairach coordinate system. The 3D spatial extents of each patient's sulci were compared with their disease severity based on neuropsychological performance. The 3D sulcal variability, within the "normalized" atlas space, ranged from 4.0 mm for the left callosal sulcus to 9.1 mm for the ...Continue Reading
References
Apr 1, 1975·Journal of Psychiatric Research·B J Cohler
Jan 1, 1992·Neurology·L P Rowland
Jan 1, 1991·Radiology·J W Gurney
Jan 1, 1990·Neurology·Y SternR Mayeux
Jul 1, 1981·Annals of Neurology·J W Lance
Feb 1, 1996·NeuroImage·E M WassermannM Hallett
Citations
Apr 27, 2001·The Anatomical Record·A W Toga, P M Thompson
Dec 31, 1998·Psychiatry Research·T DierksK Maurer
Oct 28, 2004·Neuropsychology·Temitayo OyegbileBruce P Hermann
Nov 23, 2006·Nature Reviews. Neuroscience·Arthur W TogaKarl Zilles
Aug 17, 2000·The New England Journal of Medicine·S Y BookheimerG W Small
Feb 10, 2000·Journal of Computer Assisted Tomography·I D DinovA W Toga
May 17, 2005·Alcoholism, Clinical and Experimental Research·Elsa DaurignacDaniel Mathalon
Oct 30, 2010·Neuropsychologia·Katherine L PossinJoel H Kramer
Mar 1, 2012·International Journal of Geriatric Psychiatry·Laura B Zahodne, Geoffrey Tremont
Sep 26, 2006·NeuroImage·Alex FornitoMurat Yücel
Oct 11, 2005·Magnetic Resonance Imaging·Bang-Bon KooSun I Kim
Aug 31, 2001·Biological Psychiatry·K L NarrA W Toga
Mar 15, 2011·NeuroImage·Tao LiuPerminder S Sachdev
Dec 13, 2000·Cerebral Cortex·P M ThompsonA W Toga
Oct 7, 2003·Annual Review of Biomedical Engineering·Arthur W Toga, Paul M Thompson
Jan 5, 2000·Human Brain Mapping·R HeunW Grodd
Feb 15, 2017·Scientific Reports·Xuehu WeiTianzi Jiang
Mar 21, 2000·Nature·P M ThompsonA W Toga
Sep 8, 2011·Human Brain Mapping·Joana Braga PereiraEduardo Tolosa
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Jul 10, 2019·Frontiers in Aging Neuroscience·Yunyan XieTianyi Yan
Feb 23, 2021·Frontiers in Aging Neuroscience·Hsin-Yu LinChing-Po Lin