Sulcal variability in the Alzheimer's brain: correlations with cognition

Neurology
M S MegaA W Toga

Abstract

We mapped the three dimensional (3D) extents and variability of selected sulci in the Alzheimer's brain and explored the relationship between sulcal pattern and patient's cognitive performance. High-resolution MRIs of 10 patients with probable Alzheimer's disease (AD) were linearly transformed into a standard "normalized" 3D atlas (known as the Talairach coordinate system) and, on each relevant slice, contours of the left and right Sylvian fissure, anterior and posterior calcarine, callosal, parietooccipital, and cingulate sulci and the floor of the temporal horn of the lateral ventricle were traced. These landmarks were chosen because of their relative invariant location across individuals and because they demarcate functional boundaries relevant in AD. The sulcal contours were resolved into two-dimensional surfaces that cut through a brain volume. All 10 patients' sulcal surfaces were averaged to determine their mean spatial locations in the Talairach coordinate system. The 3D spatial extents of each patient's sulci were compared with their disease severity based on neuropsychological performance. The 3D sulcal variability, within the "normalized" atlas space, ranged from 4.0 mm for the left callosal sulcus to 9.1 mm for the ...Continue Reading

Citations

Apr 27, 2001·The Anatomical Record·A W Toga, P M Thompson
Nov 23, 2006·Nature Reviews. Neuroscience·Arthur W TogaKarl Zilles
Aug 17, 2000·The New England Journal of Medicine·S Y BookheimerG W Small
Feb 10, 2000·Journal of Computer Assisted Tomography·I D DinovA W Toga
Mar 1, 2012·International Journal of Geriatric Psychiatry·Laura B Zahodne, Geoffrey Tremont
Oct 11, 2005·Magnetic Resonance Imaging·Bang-Bon KooSun I Kim
Oct 7, 2003·Annual Review of Biomedical Engineering·Arthur W Toga, Paul M Thompson
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Feb 23, 2021·Frontiers in Aging Neuroscience·Hsin-Yu LinChing-Po Lin

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