Sulfadimethoxine and ormetoprim residues in three species of fish after oral dosing in feed

Journal of Aquatic Animal Health
R E KosoffP R Bowser

Abstract

Nile tilapia Oreochromis niloticus, summer flounder Paralichthys dentatus, and walleyes Sander vitreus were treated with Romet-30 (PHARMAQ AS, Oslo, Norway) via a medicated ration at 50 mg Romet-30 kg fish body weight(- 1) d(-1) for 10 d to compare the elimination kinetics of the test substance. This study was part of a larger effort to develop a species grouping concept for the labeling of therapeutic compounds for cultured fishes. The fish tests were conducted at the ideal water temperature for each species and at 5 degrees C lower than the ideal temperature except for summer flounder, which would not feed at the lower temperature of 15 degrees C. Test temperatures were 30 degrees C and 25 degrees C for Nile tilapia, 20 degrees C and 17 degrees C for summer flounder, and 25 degrees C and 20 degrees C for walleyes. Neither component of Romet-30 (sulfadimethoxine and ormetoprim) could be detected in samples of the edible portion of walleyes (muscle plus skin) collected at day 10 posttreatment or thereafter. In studies with summer flounder, only one fish had a detectable concentration of either component on day 21 or thereafter. Elimination of Romet-30 by Nile tilapia was extremely rapid. The limited number of Nile tilapia with ...Continue Reading

References

Feb 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B F DroyK M Kleinow
Oct 14, 1994·Journal of Chromatography. B, Biomedical Applications·O B Samuelsen

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Citations

Dec 6, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Ana Paula FaisJonas Augusto Rizzato Paschoal
Jun 3, 2009·Journal of Aquatic Animal Health·R E KosoffL A Tell
Apr 14, 2018·Neotropical Entomology·L A Leite-RossiS Trivinho-Strixino

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