PMID: 6144268May 1, 1984

Sulfasalazine hepatotoxicity

The American Journal of Gastroenterology
A FichD Rachmilewitz


Hepatotoxicity has been recently described as a rare complication of sulfasalazine therapy. Two patients with hepatic damage after sulfasalazine treatment are reported. Liver biopsy performed in one patient revealed granulomatous hepatitis. On rechallenge with 5 aminosalicylic acid enema the second patient developed a hypersensitivity reaction without hepatic involvement.

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