PMID: 2572687Aug 1, 1989

Sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, and erythroid hypoplasia

Journal of Pediatric Gastroenterology and Nutrition
David A GremseM S Moyer

Abstract

Sulfasalazine, a commonly prescribed drug for the treatment of inflammatory bowel disease, can cause an allergic reaction with hepatotoxicity, lymphadenopathy, and rash. In addition, many hematologic complications have been observed with sulfasalazine, including aplastic anemia, thrombocytopenia, and erythroid hypoplasia. However, thrombocytopenia in association with sulfasalazine hypersensitivity has not been previously reported. We report a child who developed severe thrombocytopenia and anemia during a hypersensitivity reaction to sulfasalazine.

Citations

Apr 30, 2013·International Journal of Clinical Pharmacy·Yuefeng Rao, Feiyue Zheng
Feb 1, 1996·Pediatric Clinics of North America·B S Kirschner
Jun 12, 2009·Cutaneous and Ocular Toxicology·Didem Didar BalciCigdem Asena Dogramaci
Sep 1, 1994·Clinical and Experimental Dermatology·K E McKenna, D Burrows
Nov 15, 2002·Paediatric Drugs·David A Gremse, Karen D Crissinger

Related Concepts

Anemia
Bone Marrow Diseases
Drug Allergy
Sulfasalazin medac
Thrombocytopenia
Inflammatory Bowel Diseases
Drug-Induced Acute Liver Injury

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