Dec 1, 1986

Sulfasalazine in rheumatoid arthritis. A double-blind, placebo-controlled trial

Arthritis and Rheumatism
R S PinalsB Hepburn


Sulfasalazine (SSZ), 3 gm daily, was compared with placebo for treatment of rheumatoid arthritis, in a 15-week randomized, parallel, double-blind trial. Joint tenderness and swelling, morning stiffness, grip strength, and pain score all showed significantly more improvement with SSZ than with placebo. Adverse effects, particularly gastrointestinal reactions, led to withdrawal from the study of 28% of the patients who had been receiving SSZ, but these effects were all readily reversible and not life-threatening. These results confirm previous findings that suppression of rheumatoid synovitis may be induced by SSZ, within 2 months after full maintenance doses are reached.

Mentioned in this Paper

Reaction Time
Sulfasalazin medac
Rheumatoid Arthritis
Clinical Trials
Drug Toxicity
Double-Blind Method

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