PMID: 2901839Sep 1, 1988

Sulfasalazine in the treatment of ankylosing spondylitis. A twenty-six-week, placebo-controlled clinical trial

Arthritis and Rheumatism
M NissiläU Yli-Kerttula


Eighty-five patients with active ankylosing spondylitis (AS) were randomized to receive either sulfasalazine (less than or equal to 3 gm/day, mean 2.5) or placebo for 26 weeks. There was a statistically significant improvement, compared with baseline, in most of the clinical variables in patients receiving the active drug. Laboratory parameters (erythrocyte sedimentation rate, C-reactive protein, IgG, IgM, and IgA) also improved during the active treatment, suggesting a beneficial effect of sulfasalazine on AS. At the end of the treatment, significant differences between the sulfasalazine and placebo groups were observed in morning stiffness, chest expansion, erythrocyte sedimentation rate, and in all immunoglobulin classes. Two patients in each treatment group discontinued the trial because of side effects. Enteric-coated sulfasalazine seemed to be effective and well tolerated in patients with active AS.


Mar 1, 1985·Annals of the Rheumatic Diseases·J A Trapani, I F McKenzie
May 1, 1986·Annals of the Rheumatic Diseases·N Feltelius, R Hällgren
Oct 11, 1986·British Medical Journal·Maxime DougadosB Amor
Dec 1, 1986·Arthritis and Rheumatism·R S PinalsB Hepburn
Jul 1, 1986·Annals of the Rheumatic Diseases·L E McGuiganH V Bashir
Feb 16, 1980·British Medical Journal·B McConkeyL Walsh
Jan 1, 1981·Scandinavian Journal of Gastroenterology·D DanielssonG Järnerot
Feb 1, 1984·British Journal of Rheumatology·T Pullar, H A Capell
Nov 1, 1983·British Journal of Rheumatology·A Ebringer
Apr 1, 1984·Annals of the Rheumatic Diseases·C T PeaseH L Currey
Nov 1, 1981·Journal of Medical Microbiology·R ShinebaumV Wright
Dec 1, 1981·Annals of the Rheumatic Diseases·M CalguneriV Wright
Feb 1, 1980·Annals of the Rheumatic Diseases·R E Warren, D A Brewerton
Dec 1, 1980·Annals of the Rheumatic Diseases·P CowlingA Ebringer


Nov 7, 1998·Clinical Rheumatology·J L Huang, L C Chen
Jun 30, 2009·Rheumatology International·L Goh, A Samanta
Nov 1, 1990·Immunopharmacology·F ShanahanP Anton
Jun 16, 2005·Current Opinion in Rheumatology·J Zochling, Jürgen Braun
Sep 1, 1991·The British Journal of Dermatology·A J Carmichael, C J Paul
Aug 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J J AndreasenP Helin
Aug 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Leirisalo-Repo
Aug 1, 1992·Annals of the Rheumatic Diseases·Maxime DougadosB Amor
Dec 4, 2013·Annals of the Rheumatic Diseases·Henning Zeidler, Alan P Hudson
Dec 10, 2014·Best Practice & Research. Clinical Rheumatology·Enrique Roberto SorianoLiron Caplan
Jul 2, 2005·Expert Opinion on Emerging Drugs·J Sieper, Jürgen Braun
Dec 16, 2000·Expert Opinion on Investigational Drugs·E Toussirot, D Wendling
Jun 17, 2006·Best Practice & Research. Clinical Rheumatology·Nurullah AkkocMuhammad Asim Khan
Aug 1, 1991·Baillière's Clinical Rheumatology·R Laurent
Dec 1, 1990·Baillière's Clinical Rheumatology·D R Porter, H A Capell
Jan 19, 1999·Rheumatic Diseases Clinics of North America·F De KeyserE M Veys
Jan 1, 1990·Scandinavian Journal of Rheumatology. Supplement·M Leirisalo-Repo
Jan 1, 1992·Scandinavian Journal of Rheumatology·J V ViitanenH Takala
Jan 1, 2015·Nature Reviews. Disease Primers·J SieperDominique Baeten
Feb 1, 1996·Baillière's Clinical Rheumatology·H MielantsM De Vos
Jun 30, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jing-Jing MaXuan Yao
Jul 25, 2017·International Journal of Rheumatic Diseases·Shefali Khanna SharmaVarun Dhir
Jun 24, 2017·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Mesut Öğrendik
Jul 29, 2006·Arthritis and Rheumatism·Walter P MaksymowychAnthony S Russell
Jan 1, 1994·Scandinavian Journal of Rheumatology·K Laasila, M Leirisalo-Repo
Nov 28, 2014·The Cochrane Database of Systematic Reviews·Junmin ChenChao Liu
Dec 14, 2019·Nature Reviews. Rheumatology·Kathryn M KingsmorePeter E Lipsky
Jun 20, 2020·Expert Opinion on Drug Metabolism & Toxicology·Francesca MarinoFabiola Atzeni
Apr 1, 1992·The Journal of International Medical Research·I CarusoS Santandrea

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