Sulfasalazine prevents apoptosis in spermatogenic cells after experimental testicular torsion/detorsion

Acta Pharmacologica Sinica
Yu-Gang ZhaoZhi-Yun Yu

Abstract

To determine whether sulfasalazine can prevent apoptosis in spermatogenic cells by preventing the activation of NF-kappaB in spermatogenic epithelium in experimental testicular torsion. Thirty-two adult male Sprague-Dawley rats were subjected to unilateral 720 degree testicular torsion for durations of 0 h and 2 h, then the torsion was relieved. The ischemic/reperfused testes were collected for the detection of NF-kappaB expression with Western blotting and immunohistochemistry techniques, and detection of apoptosis with TUNEL techniques. The NF-kappaB coefficient of spermatogenic epithelium and the apoptosis index of spermatogenic cells were significantly different in the operation and the sham-operation groups after experimental testicular torsion (P<0.01). NF-kappaB activation of spermatogenic epithelium is related to apoptosis of spermatogenic cells. Sulfasalazine can prevent apoptosis in spermatogenic cells after the experimental testicular torsion through prevention of NF-kappaB activation.

References

Sep 1, 1989·The Journal of Urology·J H BaradaW J Cromie
Dec 1, 1986·British Journal of Urology·J B Anderson, R C Williamson
Jul 1, 1985·The British Journal of Surgery·R C Williamson
Feb 1, 1994·The Journal of Experimental Medicine·M A ReadT Collins
Aug 1, 1993·Biology of Reproduction·T T Turner, K J Brown
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Jul 1, 1997·American Journal of Respiratory Cell and Molecular Biology·T S Blackwell, J W Christman
Nov 18, 1997·Cell·I Stancovski, D Baltimore
Jan 4, 1998·Biology of Reproduction·T T TurnerL W Wilson
Apr 16, 1998·The Journal of Clinical Investigation·C WahlR M Schmid
Dec 22, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·B T FeeleyR C Robbins
May 2, 2002·ANZ Journal of Surgery·Robert D Smith
Jul 20, 2002·Free Radical Biology & Medicine·Kevin P PavlickMatthew B Grisham

❮ Previous
Next ❯

Citations

May 29, 2009·Clinical and Experimental Pharmacology & Physiology·M BertolottoFabrizio Montecucco
Jun 18, 2014·Nature Reviews. Urology·Ersagun KaraguzelOmer Kutlu
Jul 21, 2012·Journal of Pediatric Surgery·Akihide SugiyamaAkira Toki
Jul 20, 2010·The Journal of Urology·Stone YangChun-Jen Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis