PMID: 8587078May 1, 1995Paper

Sulfasalazine therapy for psoriatic arthritis: a double blind, placebo controlled trial

The Journal of Rheumatology
A K GuptaW J McCune

Abstract

Psoriatic arthritis (PsA) is often poorly responsive to 2nd line antirheumatic drug therapy. Sulfasalazine has recently gained wide acceptance in the treatment of rheumatoid arthritis, and beneficial effects have also been noted in ankylosing spondylitis and reactive arthritis. We report a double blind placebo controlled study of sulfasalazine in PsA. Twenty-four patients with active PsA were randomized to receive either sulfasalazine (3 g/day) (n = 10) or placebo (n = 14) for 8 weeks, in a double blind manner, followed by an 8 week open label crossover phase for nonresponding placebo patients. Compared with placebo controls, sulfasalazine treated patients were significantly improved at Weeks 4 and 8 with respect to physician (p < 0.01) and patient (p < 0.05) global assessments. Duration of morning stiffness was significantly decreased at Week 8 (p < 0.01). Clinical variables of disease activity returned to baseline after a 4 week drug washout period in 5 evaluable patients. Six patients in the placebo group crossed over to an 8 week open label phase and demonstrated significant improvements in joint scores, 50 ft walking time, and global patient assessment. Sulfasalazine treated patients also showed significant improvements in...Continue Reading

Citations

Jan 15, 2004·Annals of the Rheumatic Diseases·S P McKennaD J Veale
Jul 2, 2004·Arthritis Research & Therapy·Alice B Gottlieb, Christian E Antoni
Feb 15, 2005·Annals of the Rheumatic Diseases·P Nash, D O Clegg
Feb 15, 2005·Annals of the Rheumatic Diseases·L S WinterfieldA Gottlieb
Feb 22, 2012·Rheumatology·Gabrielle H KingsleyDavid L Scott
Feb 19, 2009·Dermatologic Therapy·Dafna D Gladman
Jan 5, 2011·International Journal of Rheumatic Diseases·Fabrizio CantiniEmanuele Cassarà

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