Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tract

Oncotarget
Hsiang-Ying LeeChien-Feng Li

Abstract

Urothelial carcinoma (UC), arising from the urothelium of the urinary tract, can occur in the upper (UTUC) and the urinary bladder (UBUC). A representative molecular aberration for UC characteristics and prognosis remains unclear. Data mining of Gene Expression Omnibus focusing on UBUC, we identified sulfatase-1 (SULF1) upregulation is associated with UC progression. SULF1 controls the sulfation status of heparan sulfate proteoglycans and plays a role in tumor growth and metastasis, while its role is unexplored in UC. To first elucidate the clinical significance of SULF1 transcript expression, real-time quantitative RT-PCR was performed in a pilot study of 24 UTUC and 24 UBUC fresh samples. We identified that increased SULF1 transcript abundance was associated with higher primary tumor (pT) status. By testing SULF1 immunoexpression in independent UTUC and UBUC cohorts consisted of 340 and 295 cases, respectively, high SULF1 expression was significantly associated with advanced pT and nodal status, higher histological grade and presence of vascular invasion in both UTUC and UBUC. In multivariate survival analyses, high SULF1 expression was independently associated with worse DSS (UTUC hazard ratio [HR] = 3.574, P < 0.001; UBUC H...Continue Reading

References

Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·W ZoliA Gasperi-Campani
Oct 9, 2002·The Journal of Biological Chemistry·Megumi Morimoto-TomitaSteven D Rosen
Oct 27, 2004·Apoptosis : an International Journal on Programmed Cell Death·M OsakiH Ito
Jun 17, 2006·Cancer Research·Keishi NaritaViji Shridhar
Apr 27, 2007·Nature·Joseph R BishopJeffrey D Esko
May 27, 2008·The Journal of Biological Chemistry·Xinping YueJoseph A Lasky
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Alessandro OriDavid Garth Fernig
Feb 17, 2009·World Journal of Urology·Martine PloegLambertus A Kiemeney
Jun 13, 2009·The Journal of Biological Chemistry·Renhong Tang, Steven D Rosen
Aug 12, 2009·The Journal of Biological Chemistry·Marc-André FreseThomas Dierks
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Dong Yan, Xinhua Lin
Jun 18, 2011·World Journal of Urology·Grégory VerhoestKarim Bensalah
Jun 22, 2011·Cold Spring Harbor Perspectives in Biology·Stephane SarrazinJeffrey D Esko
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amal SeffouhRomain R Vivès
Apr 2, 2013·European Urology·Morgan RouprêtUNKNOWN European Association of Urology
Jan 25, 2014·Frontiers in Oncology·Romain R VivèsHugues Lortat-Jacob
Nov 5, 2015·Oncotarget·Rachel Hiu Ha ChingTerence Kin Wah Lee

❮ Previous
Next ❯

Citations

Oct 27, 2017·Scientific Reports·Jihuan ChenPietro Paolo Sanna
Jun 13, 2019·Journal of Oncology·Md Nazim UddinXiaosheng Wang
May 31, 2018·Cancer Biomarkers : Section a of Disease Markers·Yunxiao LyuSicong Zhao
Aug 8, 2021·International Journal of Molecular Sciences·Tan Phát PhamReinier A Boon
Feb 23, 2020·Journal of the American Chemical Society·Li-Ting ChiuShang-Cheng Hung

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE32894
GSE31684

Methods Mentioned

BETA
xenografts
Assay
ELISA

Software Mentioned

Nexus Expression
SPSS

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.