Sulfate conjugation of benzo[alpha]pyrene metabolites and derivates

Chemico-biological Interactions
N NemotoH V Gelboin

Abstract

Sulfate conjugation of benzo[alpha]pyrene(BP) metabolites and derivatives was studied. The reaction sequence consisted of two steps; activation of sulfate ion to 3'-phosphoadenosine-5'-phosphosulfate and transfer of the activated sulfate to the BP-derivatives. Both reactions were carried out by enzymes located in the rat liver 105 000 g supernatant. The reactions required MgCl2. Phenol and quinone derivatives were generally good substrates for sulfate conjugation and different reactivities were observed with the dihydrodiol derivatives. Sulfate conjugates were more polar than their parent BP-derivatives and except for quinone conjugates were easily extracted with ethyl acetate. The role of sulfate conjugation in BP carcinogenesis is discussed.

References

Oct 1, 1975·Archives of Biochemistry and Biophysics·N Nemoto, H Gelboin
Feb 9, 1976·Biochemical and Biophysical Research Communications·P G WislockiA H Conney
Mar 15, 1977·Biochemical Pharmacology·G M CohenJ W Bridges
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E HubermanV Gelboin
Jan 1, 1975·Annual Review of Biochemistry·C Heidelberger
Sep 1, 1967·British Journal of Cancer·L N AndrianovJ M Vasiliev
Jan 1, 1974·Advances in Cancer Research·P Sims, P L Grover
Aug 16, 1974·Science·D M Jerina, J W Daly
Jan 1, 1969·Progress in Experimental Tumor Research·J A Miller, E C Miller
Nov 15, 1969·International Journal of Cancer. Journal International Du Cancer·M DuncanA Dipple
Nov 15, 1968·International Journal of Cancer. Journal International Du Cancer·L DiamondG H Rothblat
Apr 1, 1967·Biochemical Pharmacology·P Sims

❮ Previous
Next ❯

Citations

Jun 1, 1987·Archives of Toxicology·M MollièreG F Kahl
Jan 1, 1984·Journal of Toxicology and Environmental Health·J J GodleskiP Garbeil
Feb 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S I Rao, M W Duffel
Jun 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F KieferF J Wiebel
Oct 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P L Grover
May 21, 2016·Chemosphere·Juliana A S A OliveiraManuel J S Monte
Jan 13, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tanguy CorbelNicole Picard-Hagen
Jan 1, 1980·Annals of the New York Academy of Sciences·P OkanoH V Gelboin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.