PMID: 9420059Jan 7, 1998Paper

Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens

Antimicrobial Agents and Chemotherapy
Betsy C HeroldM D Cooper

Abstract

Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.

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Citations

Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Sara SinhaBetsy C Herold
Dec 19, 2006·Journal of Medical Microbiology·Sanaa Fadel, Adrian Eley
Apr 3, 2012·The Journal of Antimicrobial Chemotherapy·Pedro M M MesquitaBetsy C Herold
Jul 10, 2012·Glycobiology·Vaibhav TiwariDeepak Shukla
Feb 1, 2019·Frontiers in Microbiology·Karen M GallegosKyle H Ramsey
Dec 20, 2015·American Journal of Reproductive Immunology : AJRI·Niall BuckleyBetsy C Herold
Sep 4, 2001·Biotechnology & Genetic Engineering Reviews·C G KellyG Pozzi
May 25, 2004·Antimicrobial Agents and Chemotherapy·Natalia CheshenkoBetsy C Herold
Nov 13, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiara UrbinatiMarco Rusnati
Jan 31, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuh-Shyong YangYi-Chih Mao
Nov 28, 2001·Current Infectious Disease Reports·Christine Mauck, Gustavo Doncel
Dec 4, 2009·Virologica Sinica·Christopher D O'Donnell, Deepak Shukla
Dec 18, 2018·Frontiers in Pharmacology·Dominik D KaltenbachVaibhav Tiwari
Feb 5, 2021·Frontiers in Cellular and Infection Microbiology·Krishnaraju MadavarajuDeepak Shukla
Mar 7, 2021·International Journal of Molecular Sciences·Sinead CarseGeorgia Schäfer
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·B C HeroldM D Cooper
Aug 22, 2018·ACS Medicinal Chemistry Letters·Rahaman Navaz GangjiUmesh R Desai

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