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Sulfated Dendritic Polyglycerol Is a Potent Complement Inhibitor

Biomacromolecules

Oct 14, 2019

Kim SilberreisJens Dernedde

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Abstract

The complement system is a powerful mechanism of the innate immune defense system. Dysregulation may contribute to several diseases. Heparin is a known regulator of the complement system, but its application is limited due to its anticoagulative activity. A promising alternative is the ...read more

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Analogs & derivatives
Complement System Proteins
Complement C5a
Complement Activation
Enzyme-Linked Immunosorbent Assay
Heparin
Magnetic Resonance Imaging
2,3-Diphosphoglycerate
polyglycerol
Deep Gray Layer of the Superior Colliculus
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Sulfated Dendritic Polyglycerol Is a Potent Complement Inhibitor

Biomacromolecules

Oct 14, 2019

Kim SilberreisJens Dernedde

PMID: 31461260

DOI: 10.1021/acs.biomac.9b00889

Abstract

The complement system is a powerful mechanism of the innate immune defense system. Dysregulation may contribute to several diseases. Heparin is a known regulator of the complement system, but its application is limited due to its anticoagulative activity. A promising alternative is the ...read more

Mentioned in this Paper

Analogs & derivatives
Complement System Proteins
Complement C5a
Complement Activation
Enzyme-Linked Immunosorbent Assay

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