PMID: 7521140Aug 1, 1994Paper

Sulfated glycoconjugates as disrupters of Plasmodium falciparum erythrocyte rosettes

The American Journal of Tropical Medicine and Hygiene
S RogersonG V Brown

Abstract

Some strains of Plasmodium falciparum form erythrocyte rosettes that are believed to result from a lectin interaction between malaria-infected and uninfected erythrocytes. The sulfated glycoconjugate heparin and certain heparin derivatives have been observed to disrupt rosettes. To investigate this interaction further, we have studied the effects of four sulfated glycoconjugates on 15 fresh isolates of P. falciparum from Papua New Guinea. A broader range of sulfated glycoconjugates has been tested against a laboratory strain. A concentration of 1,000 micrograms/ml of dextran sulfate (molecular weight [MW] 500,000) was the most potent disrupter of rosettes. Fucoidan, heparin, and dextran sulfate (MW 5,000) were of decreasing effectiveness in 14 of 15 fresh isolates. The same relationship was true for the laboratory strain. Pentosan polysulfate and sulfatide also disrupted rosettes; chondroitin sulfates A, B, and C and keratan sulfate gave either minimal or no rosette disruption. Thus, some sulfated glycoconjugates are potent disrupters of P. falciparum erythrocyte rosettes. Sulfated glycoconjugates that are potent disrupters of P. falciparum rosettes may prove useful in identifying ligands involved in rosette formation.

Citations

Sep 8, 2010·Expert Review of Anti-infective Therapy·Chandy C JohnRobert O Opoka
Apr 14, 2016·Drug Delivery and Translational Research·Miloni Thakkar, Brijesh S
Jul 19, 2019·Frontiers in Immunology·Wenn-Chyau LeeLaurent Rénia
Jan 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J RogersonG V Brown
Jan 25, 2018·Malaria Journal·Rosauro VaroQuique Bassat
Dec 22, 1999·Infection and Immunity·S J RogersonM E Molyneux
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alexandre JuilleratGraham A Bentley
Sep 13, 2011·Expert Review of Anti-infective Therapy·Sarah J HigginsW Conrad Liles
Sep 3, 2020·Pharmaceutics·Elena LanteroXavier Fernàndez-Busquets

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