Sulfated hyaluronan derivatives reduce the proliferation rate of primary rat calvarial osteoblasts.

Glycoconjugate Journal
Reiner KunzePeter Dieter

Abstract

Glycosaminoglycans (GAG) and proteoglycans, which are components of the extracellular bone matrix, are also localized in and at the membrane of osteoblasts and in the pericellular matrix. Due to their interaction with several growth factors, water and cations these molecules play an important role in regulating proliferation and differentiation of osteoblasts and bone development. The aim of this study was to assess in vitro the effects of two chemically sulfated hyaluronan (HyaS) derivatives on the proliferation of rat calvarial osteoblasts and to compare with those of native hyaluronan (Hya) and natural sulfated GAG such as chondroitin-4-sulfate (C4S), chondroitin-6-sulfate (C6S), dermatan sulfate (DS) and heparan sulfate (HS). Moderately and highly sulfated HyaS derivatives caused a time-dependent reduction of osteoblast proliferation. The anti-proliferative effect of HyaS was accompanied by a cell cycle arrest in the G1 phase, but was not associated with cell death. Whereas non-sulfated high molecular weight (HMW)- and low molecular weight (LMW)-Hya as well as C4S, C6S, DS and HS showed no effect on the cell proliferation.

References

Feb 1, 1996·Thrombosis Research·A MagnaniR Barbucci
Nov 5, 1999·Archives of Biochemistry and Biophysics·H G GargR J Linhardt
Jul 6, 2000·Journal of Biomedical Materials Research·U GeisslerK Wenzel
Sep 16, 2000·Carbohydrate Research·L NajiK Arnold
Aug 15, 2001·Seminars in Arthritis and Rheumatism·J P BaliE Neuzil
Aug 20, 2003·Journal of Biomedical Materials Research. Part a·L HuangS M Kumta
Sep 16, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·U HempelK W Wenzel
May 12, 2005·The International Journal of Biochemistry & Cell Biology·Simon M Cool, Victor Nurcombe
Sep 17, 2005·Glycobiology·Tadahiro IsoyamaVinata B Lokeshwar
Jan 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristen R Taylor, Richard L Gallo
Jul 11, 2006·Journal of Cellular Physiology·Kerry J MantonVictor Nurcombe
Oct 20, 2006·Journal of Cellular Physiology·Rebecca A JacksonSimon M Cool
Feb 14, 2007·The Journal of Cell Biology·Devashish KothapalliRichard K Assoian
Jul 27, 2007·Journal of Molecular Histology·Kerry J MantonSimon M Cool
Aug 9, 2007·Journal of Molecular Histology·Martin GrünertVictor Nurcombe
Sep 23, 2008·The Journal of Biological Chemistry·Devashish KothapalliRichard K Assoian

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Citations

Dec 22, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Juliane SalbachLorenz C Hofbauer
Oct 12, 2013·Journal of Materials Science. Materials in Medicine·Matthias C SchulzVera Hintze
Mar 9, 2012·Biochemistry Research International·Mairim Alexandra SolisLynn L H Huang
Dec 21, 2013·Journal of Cellular Biochemistry·Juliane Salbach-HirschLorenz C Hofbauer
Nov 22, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bernd StadlingerUwe Eckelt
Nov 14, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Daniel Gonçalves BoeckelEduardo Rolim Teixeira
Sep 12, 2015·Journal of Materials Science. Materials in Medicine·Dieter ScharnweberVera Hintze
Aug 4, 2015·Biomaterials·Juliane Salbach-HirschLorenz C Hofbauer
May 27, 2015·Journal of Tissue Engineering and Regenerative Medicine·Anja van der SmissenUlf Anderegg
Jan 27, 2017·Biomacromolecules·Christian KascholkeMichael C Hacker
Nov 26, 2015·Molecular & Cellular Proteomics : MCP·Johannes R SchmidtStefan Kalkhof
Mar 14, 2019·The Journal of Craniofacial Surgery·Daniel Goncalves BoeckelEduardo Rolim Teixeira
Jul 2, 2017·Journal of Cellular Physiology·Sabine SchulzeUte Hempel
Sep 8, 2020·Journal of Tissue Engineering and Regenerative Medicine·Franziska ClauderAnnette G Beck-Sickinger

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