PMID: 9533896May 30, 1998Paper

Sulfated polysaccharides block chlamydia infection in vitro, but do not protect mice from vaginal inoculation

Microbial Pathogenesis
C A BurilloD M Phillips

Abstract

There is considerable interest in developing a vaginal product that women could use to protect themselves from sexually transmitted pathogens, including chlamydia. It has been suggested that sulfated polysaccharides would be effective in a prophylactic product because they have been shown to block infection of cultured cells by sexually transmitted pathogens, including chlamydia. In order to compare in vitro findings with animals, we placed sulfated polysaccharides into the vaginae of mice prior to inoculation with chlamydia. The surfactant nonoxynol 9 (N9) was used as a positive control as it has been previously shown to protect mice from infection by chlamydia. In this study, N9 also protected the mice from infection. However, sulfated polysaccharides which had been shown to be efficacious in vitro did not block infection.

References

Apr 1, 1976·Infection and Immunity·C C Kuo, T Grayston
May 29, 1992·Cell·J P Zhang, R S Stephens
Sep 1, 1988·The Journal of Infectious Diseases·W C LouvJ Cheeks
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Oct 1, 1993·The Journal of Infectious Diseases·K J WhaleyR A Cone

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Citations

Jun 3, 2006·BMC Infectious Diseases·Richard A ConeThomas R Moench
Nov 20, 2002·Sexually Transmitted Diseases·Sharon L AchillesRichard A Cone
Aug 28, 2018·Journal of Applied Phycology·Aleksandra Inic-KanadaTalin Barisani-Asenbauer

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