Sulfatide is required for efficient replication of influenza A virus.

Journal of Virology
Tadanobu TakahashiTakashi Suzuki

Abstract

Sulfatide is abundantly expressed in various mammalian organs, including the intestines and trachea, in which influenza A viruses (IAVs) replicate. However, the function of sulfatide in IAV infection remains unknown. Sulfatide is synthesized by two transferases, ceramide galactosyltransferase (CGT) and cerebroside sulfotransferase (CST), and is degraded by arylsulfatase A (ASA). In this study, we demonstrated that sulfatide enhanced IAV replication through efficient translocation of the newly synthesized IAV nucleoprotein (NP) from the nucleus to the cytoplasm, by using genetically produced cells in which sulfatide expression was down-regulated by RNA interference against CST mRNA or overexpression of the ASA gene and in which sulfatide expression was up-regulated by overexpression of both the CST and CGT genes. Treatment of IAV-infected cells with an antisulfatide monoclonal antibody (MAb) or an anti-hemagglutinin (HA) MAb, which blocks the binding of IAV and sulfatide, resulted in a significant reduction in IAV replication and accumulation of the viral NP in the nucleus. Furthermore, antisulfatide MAb protected mice against lethal challenge with pathogenic influenza A/WSN/33 (H1N1) virus. These results indicate that associati...Continue Reading

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Citations

Apr 23, 2013·Glycoconjugate Journal·Tadanobu TakahashiTakashi Suzuki
Jul 24, 2012·Journal of Biochemistry·Tadanobu TakahashiTakashi Suzuki
Dec 23, 2011·Biochemistry Research International·Tadanobu Takahashi, Takashi Suzuki
May 24, 2012·Journal of Lipid Research·Tadanobu Takahashi, Takashi Suzuki
Jul 3, 2009·Biological & Pharmaceutical Bulletin·Repon Kumer SahaTakashi Suzuki
Jul 2, 2011·Biological & Pharmaceutical Bulletin·Keijo FukushimaTakashi Suzuki
Apr 12, 2013·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Koichi Honke
Aug 5, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tadanobu Takahashi
Aug 12, 2014·Biological & Pharmaceutical Bulletin·Tadanobu TakahashiTakashi Suzuki
Jun 2, 2015·Biological & Pharmaceutical Bulletin·Tadanobu Takahashi, Takashi Suzuki
Jul 10, 2010·Antiviral Research·Repon Kumer SahaTakashi Suzuki
Aug 4, 2015·Biological & Pharmaceutical Bulletin·Tadanobu TakahashiTakashi Suzuki
May 11, 2011·Biology of the Cell·Julien PerinoAnne-Laure Favier
Sep 23, 2014·Journal of Virological Methods·Tadanobu TakahashiTakashi Suzuki
May 3, 2014·Scientific Reports·Yuuki KurebayashiTakashi Suzuki
Mar 26, 2019·Analytical Chemistry·Yi-Min SheTerry D Cyr
May 24, 2019·ACS Chemical Biology·Yuuki KurebayashiTakashi Suzuki

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