Sulfation made simple: a strategy for synthesising sulfated molecules

Chemical Communications : Chem Comm
Daniel M GillAlan M Jones

Abstract

The study of organosulfates is a burgeoning area in biology, yet there are significant challenges with their synthesis. We report the development of a tributylsulfoammonium betaine as a high yielding route to organosulfates. The optimised reaction conditions were interrogated with a diverse range of alcohols, including natural products and amino acids.

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Citations

Jul 5, 2019·The Journal of Biological Chemistry·Süleyman GünalJonathan Wolf Mueller
Oct 8, 2020·Scientific Reports·Jaber A AlshehriAlan M Jones
Nov 5, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Alan M Jones
Nov 7, 2019·Chembiochem : a European Journal of Chemical Biology·Anna Mary BenedettiAlan M Jones
Jan 17, 2021·Molecular and Cellular Endocrinology·Thomas Alec LightningJonathan Wolf Mueller
Mar 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Jonathan Wolf MuellerMatthias Kroiss

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Methods Mentioned

BETA
ion-exchange chromatography
NMR
X-ray

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