PMID: 11343803May 10, 2001Paper

Sulfide is an efficient iron releasing agent for mammalian ferritins

Biochimica Et Biophysica Acta
S Cassanelli, J Moulis

Abstract

The most prominent role of mammalian ferritins is to provide an extensive iron-buffering capacity to cells. The large ferritin iron stores can be mobilized in vitro, but the functional relevance of the most efficient iron releasing agents remains elusive. Sulfide is a strongly reducing chemical generated by a series of enzymes. In the presence of limited amounts of sulfide a continuous rate of iron release from ferritin was observed and a majority of the protein iron core was recovered in solution. The rate constants for iron efflux triggered by several reducing or chelating compounds have been measured and compared. Although not as efficient as reduced flavins, sulfide displayed kinetic parameters which suggest a potential physiological role for the chalcogenide in converting the iron storage protein into apoferritin. To further probe the relevance of sulfide in the mobilization of iron, several enzymes, such as NifS, rhodanese, or sulfite reductase generating reduced forms of sulfur by different mechanisms, have been assayed for their ability to catalyze the release of iron from ferritin. The results show that full reduction of sulfur into sulfide is needed to deplete iron from ferritin. These reactions suggest links between ...Continue Reading

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Citations

Jan 11, 2005·Neurotoxicity Research·Juan Segura Aguilar, Richard M Kostrzewa
Feb 8, 2011·Journal of Neural Transmission·Esther G Meyron-HoltzLyora A Cohen
Jun 27, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Koichi SakuraiYukio Fujimoto
Jun 5, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jonas Hälldin, Tiit Land
May 15, 2015·Biomolecules·Nikolaus Bresgen, Peter M Eckl
Oct 22, 2008·Biochimica Et Biophysica Acta·Paolo ArosioPatrizia Cavadini
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Nov 27, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Toshihiko Ubuka
May 21, 2021·Frontiers in Cellular and Infection Microbiology·Kari E MurrosPer E J Saris

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