Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system

Colloids and Surfaces. B, Biointerfaces
Zeynep AytacTamer Uyar

Abstract

Herein, hydroxypropyl-beta-cyclodextrin (HPβCD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HPβCD-IC-NF) via electrospinning. SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HPβCD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HPβCD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HPβCD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HPβCD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HPβCD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HPβCD-IC-NF). Consequently, PCL-HPC/SFS/HPβCD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HPβCD-IC-NF. This study may provide more effici...Continue Reading

References

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Nov 23, 2013·Colloids and Surfaces. B, Biointerfaces·Asli CelebiogluTamer Uyar

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Citations

Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Zeynep AytacTamer Uyar
May 21, 2016·Biomaterials Science·Young-Jin KimYukiko T Matsunaga
Oct 25, 2016·International Journal of Pharmaceutics·Safa OuerghemmiBernard Martel
Oct 25, 2016·International Journal of Pharmaceutics·Alejandro CostoyaCarmen Alvarez-Lorenzo
Feb 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro CostoyaCarmen Alvarez-Lorenzo
Jul 25, 2017·Journal of Agricultural and Food Chemistry·Jie XiaoQingrong Huang
Jul 26, 2019·Journal of Biomaterials Applications·Atike Ince YardimciYusuf Selamet
Oct 12, 2019·International Journal of Molecular Sciences·Daniel Fernández-VillaLuis Rojo
Nov 9, 2019·Recent Patents on Nanotechnology·Na LiChunyan Wei
May 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bastien MichelKristin Syverud
Aug 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bartłomiej KostTadeusz Biela
Jul 22, 2018·Frontiers in Chemistry·Tânia F CovaArtur J M Valente
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan LiuXiao Han
Apr 17, 2018·ACS Applied Materials & Interfaces·Sefika OzcanAyse Asatekin

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