Sulfolobus solfataricus translation initiation factor 1 stimulates translation initiation complex formation

RNA
David HasenöhrlUdo Bläsi

Abstract

The eukaryotic translation initiation factor 1 binds to the ribosome during translation initiation. It is instrumental for initiator-tRNA and mRNA binding, and has a function in selection of the authentic start codon. Here, we show that the archaeal homolog aIF1 has analogous functions. The aIF1 protein of the archaeon Sulfolobus solfataricus is bound to the small ribosomal subunit during translation initiation and accelerates binding of initiator-tRNA and mRNA to the ribosome. Accordingly, aIF1 stimulated translation of an mRNA in a S. solfataricus in vitro translation system. Moreover, this study suggested that the C terminus of the factor is of relevance for its function.

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Citations

Feb 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·David HasenöhrlUdo Bläsi
Feb 9, 2016·Future Microbiology·Jeetendra Kumar NagShailja Misra-Bhattacharya
Nov 26, 2010·Plasmid·Melinda D CapesShiladitya DasSarma
Jul 7, 2009·Research in Microbiology·Dario Benelli, Paola Londei
Jan 24, 2007·Molecular Microbiology·Gregory S Allen, Joachim Frank
Jan 30, 2013·Biochemical Society Transactions·Dominik Esser, Bettina Siebers
Apr 3, 2018·FEBS Letters·Prerana Gogoi, Shankar Prasad Kanaujia
Feb 24, 2019·International Journal of Molecular Sciences·Emmanuelle SchmittYves Mechulam
Sep 22, 2018·Nucleic Acids Research·Auriane MonestierEmmanuelle Schmitt
Oct 20, 2020·Frontiers in Microbiology·Emmanuelle SchmittYves Mechulam
Jun 22, 2021·Frontiers in Microbiology·Federica De LiseBeatrice Cobucci-Ponzano
Jul 15, 2018·Microbiology Spectrum·Heather J Beck, Isabella Moll

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