Abstract
A series of thirteen new thiadiazole compounds were synthesized and evaluated for in vitro antifungal and antibacterial activity. All compound tested showed significant antifungal activity against all the micromycetes, compared to the commercial fungicide bifonazole. Differences in their activity depend on the substitution of different reactive groups. More specifically, best antifungal activity was shown for the synthetic analogue with methylpiperazine reactive group. Furthermore, it is apparent that different compounds reacted on different ways against bacteria. An effort was made to correlate the above mentioned differences in activity with lipophilicity studies. Furthermore, NMR and molecular modelling were used to obtain the main conformational features of a potent analogue, for future in silico studies.
References
Mar 1, 1988·Mycoses·H Hänel, W Raether
Jan 1, 1968·Advances in Heterocyclic Chemistry·J Sandström
Nov 11, 1999·Biochimica Et Biophysica Acta·E Theodoropoulou, D Marsh
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·R NaganoH Morishima
May 19, 2000·Antimicrobial Agents and Chemotherapy·J O CapobiancoP Zhong
Apr 3, 2001·Journal of Clinical Microbiology·A Espinel-Ingroff
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F C Tenover
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D C Hooper
Jan 5, 2002·Current Opinion in Pharmacology·I Chopra
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Joan C Fung-TomcDaniel P Bonner
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Kensuke NagaiPeter C Appelbaum
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Roland Leclercq, Patrice Courvalin
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Brunello OlivaIan Chopra
Apr 12, 2003·The Journal of Biological Chemistry·Jerry R ColcaAlexander S Mankin
May 23, 2003·Antimicrobial Agents and Chemotherapy·Anthony E ChoudhryKapila Ratnam
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Marc GalimandThierry Lambert
Nov 20, 2003·Chemistry and Physics of Lipids·P ZoumpoulakisT Mavromoustakos
Dec 7, 2007·Bioorganic & Medicinal Chemistry·Iraj Rahavi EzabadiAna Cirić
Oct 1, 1995·Journal of Food Protection·Rasha K DaoukElsa J Sattout
Citations
Jan 1, 2016·Environmental Monitoring and Assessment·Elżbieta WołejkoJolanta Piekut
Mar 5, 2013·Chemical Biology & Drug Design·Abhishek Kumar JainRam Kishore Agrawal
Feb 13, 2015·Frontiers in Plant Science·Yasemin Bektas, Thomas Eulgem
Jan 31, 2017·The Journal of Physical Chemistry. a·Arkadiusz MatwijczukMariusz Gagoś
Dec 5, 2012·ChemMedChem·Yijing LiGuisen Zhao
Mar 9, 2019·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Dinesh K MehtaKamal Dua
Mar 2, 2017·Journal of Fluorescence·Arkadiusz MatwijczukMariusz Gagoś
Dec 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet Çağrı KaraburunZafer Asım Kaplancıklı
Nov 25, 2018·Chemistry Central Journal·Mustafa ErAbdulilah Ece
Feb 2, 2019·Current Topics in Medicinal Chemistry·Christophe TratratMarina Soković
Nov 6, 2018·Chemistry Central Journal·Fawzia Faleh Al-BlewiEl Sayed H El Ashry
Feb 13, 2021·Archiv der Pharmazie·Alaaeldin M F GalalAtef G Hanna
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sewara J MohammedKarzan A Abdalkarim
Feb 11, 2021·Antibiotics·Ahmed RagabYousry A Ammar
May 7, 2021·Bioinorganic Chemistry and Applications·Ahmed GaberMoamen S Refat
Jul 8, 2021·ChemMedChem·Walter D GuerraSilvia M Barolo
Apr 11, 2014·Chemical Reviews·Yang HuHai-Liang Zhu