Sulfonamide allergies and outcomes related to use of potentially cross-reactive drugs in hospitalized patients

Pharmacotherapy
Brian A Hemstreet, Robert L Page

Abstract

To characterize patient-reported sulfonamide allergies, assess the influence of these allergies on drug prescribing practices, and determine the frequency and nature of adverse reactions in patients with sulfonamide allergies who receive potentially cross-reactive drugs. Prospective observational study. Tertiary care hospital. Ninety-four hospitalized adult patients with reported sulfonamide allergies. Patients were followed during their hospital stay to document prescribing of and adverse reactions to sulfonamide antibiotics and sulfonamide nonantibiotics. Allergy characteristics and prescribing of sulfonamide-containing drugs were analyzed with descriptive statistics. Trimethoprim-sulfamethoxazole (TMP-SMX) allergy was reported by 42 patients (45%), whereas 42 patients (45%) did not recall the drug to which they were allergic. Fifty-nine patients (63%) reported the allergy's physical manifestation as rash, 13 (14%) anaphylaxis, and 2 (2)% Stevens-Johnson's syndrome. Median time since last reported allergic reaction to a sulfonamide-containing agent was 20 years. Forty patients (43%) had been taking a sulfonamide nonantibiotic as an outpatient for an average of 6.2 years; 24 (60%) of those patients took furosemide. Sixteen (40...Continue Reading

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Related Concepts

Microbicides
Drug Allergy
Drug Interactions
Hospitalization
Hospitals, University
Oral History as Topic
Drug Prescriptions
Sulfonamides
Septra
Drug Utilization Review

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