Sulfonamide-induced reactions in desensitized patients with AIDS--the role of covalent protein haptenation by sulfamethoxazole

The Journal of Allergy and Clinical Immunology
R S GruchallaD J Skiest

Abstract

Adverse reactions to sulfonamides cause significant morbidity in patients with AIDS. We have demonstrated previously a approximately 40 kd sulfamethoxazole (SMX)-substituted protein in the serum of some individuals treated with SMX. The purpose of this study was to examine patients with AIDS who had undergone SMX desensitization because of a prior history of SMX allergy for the presence of SMX-haptenated serum proteins and to determine whether these proteins, SMX-specific IgG antibodies, or both predict the development of subsequent clinical reactivity. Four patients with no history of allergy and in whom SMX prophylaxis was initiated and eight patients with AIDS who had undergone SMX desensitization because of prior allergy were evaluated. SMX-conjugated serum proteins were identified with an immunoblotting assay, and SMX-specific IgG antibodies were identified by ELISA inhibition. One of the four patients receiving SMX prophylactic treatment demonstrated SMX-protein haptenation, none had detectable SMX-specific IgG antibodies, and none developed an SMX-associated reaction during the time in which they were followed. Of the eight patients who underwent SMX desensitization, six (75%) demonstrated SMX-protein haptenation, and th...Continue Reading

Citations

Mar 16, 2002·Current Allergy and Asthma Reports·Geneviève Choquet-KastylevskyJacques Descotes
May 17, 2007·Current Allergy and Asthma Reports·Carolyn C Brackett
Oct 26, 2002·Chemico-biological Interactions·Mukesh Summan, Alastair E Cribb
Nov 18, 2000·Lancet·R S Gruchalla
Dec 31, 2002·Toxicology·Munir PirmohamedB Kevin Park
Jan 12, 2001·AIDS Research and Human Retroviruses·D J NaisbittB K Park
Mar 29, 2000·Allergy·R S Gruchalla
Aug 11, 2000·Paediatric Drugs·A Romano
Nov 5, 2011·Asia Pacific Allergy·Bernard Yu-Hor Thong
Jun 11, 2004·Journal of Veterinary Pharmacology and Therapeutics·L A Trepanier
Jul 15, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S N LavergneL A Trepanier
Mar 24, 2006·Pharmacotherapy·Michael J Cawley, Ozana Lipka
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·D J NaisbittB K Park
Oct 19, 2016·Toxicology·Yat Yee WongLauren A Trepanier
Jul 4, 2008·Current Opinion in Allergy and Clinical Immunology·Sidonie Nelly LavergneDean John Naisbitt
Nov 26, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R EyanagiH Shigematsu
Aug 17, 2006·The Annals of Pharmacotherapy·Daren LinMichael J Rieder
Mar 24, 2005·The Journal of Pharmacology and Experimental Therapeutics·Sanjoy RoychowdhuryCraig K Svensson
Oct 23, 2002·Molecular Pharmacology·Tarang ManchandaMichael J Rieder
Oct 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D A HessM J Rieder
Aug 31, 2019·Chemical Research in Toxicology·Arun TailorXiaoli Meng
Sep 16, 2003·Chemical Research in Toxicology·Craig K Svensson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.