Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion

Journal of Neurotrauma
Volodymyr GerzanichJ Marc Simard

Abstract

In severe traumatic brain injury (TBI), contusions often are worsened by contusion expansion or hemorrhagic progression of contusion (HPC), which may double the original contusion volume and worsen outcome. In humans and rodents with contusion-TBI, sulfonylurea receptor 1 (SUR1) is upregulated in microvessels and astrocytes, and in rodent models, blockade of SUR1 with glibenclamide reduces HPC. SUR1 does not function by itself, but must co-assemble with either KIR6.2 or transient receptor potential cation channel subfamily M member 4 (TRPM4) to form KATP (SUR1-KIR6.2) or SUR1-TRPM4 channels, with the two having opposite effects on membrane potential. Both KIR6.2 and TRPM4 are reportedly upregulated in TBI, especially in astrocytes, but the identity and function of SUR1-regulated channels post-TBI is unknown. Here, we analyzed human and rat brain tissues after contusion-TBI to characterize SUR1, TRPM4, and KIR6.2 expression, and in the rat model, to examine the effects on HPC of inhibiting expression of the three subunits using intravenous antisense oligodeoxynucleotides (AS-ODN). Glial fibrillary acidic protein (GFAP) immunoreactivity was used to operationally define core versus penumbral tissues. In humans and rats, GFAP-negat...Continue Reading

References

Oct 1, 1995·Brain Pathology·D I GrahamT A Gennarelli
May 13, 1999·Brain Research. Molecular Brain Research·D LiuI A Simpson
Sep 25, 1999·Journal of Cellular Physiology·U GalderisiA Giordano
Jan 21, 2000·Brain Research. Molecular Brain Research·M ZhouH Abe
Apr 5, 2003·Stroke; a Journal of Cerebral Circulation·Naohiko SantaMitsuo Iida
Sep 30, 2003·Glia·Xueren ZhaoBruce G Lyeth
Jan 22, 2004·Bioconjugate Chemistry·Serguei V VinogradovAlexander V Kabanov
Apr 15, 2004·Molecular and Cellular Neurosciences·Lisa Héron-MilhavetDerek LeRoith
Jul 1, 2005·American Journal of Physiology. Cell Physiology·Fei-Fei YanShow-Ling Shyng
Jun 20, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Peter KönigWolfgang Kummer
Jun 30, 2006·Cell Calcium·Henrique ChengReinhold Penner
Aug 10, 2006·Pflügers Archiv : European journal of physiology·Joseph BryanLydia Aguilar-Bryan
Nov 15, 2006·European Journal of Pharmacology·Kenneth Beri PlougInger Jansen-Olesen
Jul 7, 2007·Neurosurgical Focus·Tatsuro KawamataYoichi Katayama
Oct 20, 2007·Journal of Neurochemistry·Mangala M SoundarapandianYouming Lu
Jul 17, 2008·Journal of Neurotrauma·Kathryn E SaatmanUNKNOWN Workshop Scientific Team and Advisory Panel Members
Nov 8, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jussi AittoniemiFrances M Ashcroft
Nov 22, 2008·Stroke; a Journal of Cerebral Circulation·J Marc SimardVolodymyr Gerzanich
Dec 10, 2008·Molecular and Cellular Endocrinology·V MarigoH Cheng
Jan 27, 2009·Nature Medicine·Volodymyr GerzanichJ Marc Simard
Jul 7, 2009·Journal of Neurosurgery·Hussein AlahmadiMichael D Cusimano
Jul 17, 2009·Journal of Neurotrauma·J Marc SimardVolodymyr Gerzanich
Apr 23, 2010·Science Translational Medicine·J Marc SimardVolodymyr Gerzanich
Nov 26, 2010·Journal of Neuropathology and Experimental Neurology·Ashish D PatelJ Marc Simard
Oct 13, 2011·Journal of Neurotrauma·David KurlandJ Marc Simard
Jun 19, 2012·Translational Stroke Research·J Marc SimardVolodymyr Gerzanich
Nov 6, 2012·Acta Pharmacologica Sinica·Hong-shuo Sun, Zhong-ping Feng
Dec 21, 2012·The Journal of Biological Chemistry·Seung Kyoon WooJ Marc Simard
Aug 24, 2013·Journal of Neuropathology and Experimental Neurology·Rupal I MehtaJ Marc Simard

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Citations

Jul 30, 2019·Journal of Neurotrauma·Howard M EisenbergErik G Hayman
Jan 16, 2020·International Journal of Molecular Sciences·Ruchira M JhaJ Marc Simard
Oct 19, 2019·Expert Opinion on Investigational Drugs·Melissa PergakisJ Marc Simard
Oct 23, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Zaynab ShakkourFiras Kobeissy
Nov 19, 2020·Journal of Neurotrauma·Ruchira M JhaPatrick M Kochanek
Mar 19, 2021·Frontiers in Cell and Developmental Biology·Katharina Held, Balázs István Tóth
Mar 17, 2021·AACN Advanced Critical Care·Maureen Scarboro, Karen A McQuillan
Feb 3, 2021·Fundamental & Clinical Pharmacology·Dominique LerouetValérie C Besson
Jul 3, 2021·International Journal of Molecular Sciences·Shotaro Michinaga, Yutaka Koyama
Aug 13, 2021·Neural Regeneration Research·Iván Alquisiras-BurgosPenélope Aguilera
Dec 1, 2021·Expert Opinion on Therapeutic Targets·Ruchira M JhaJ Marc Simard

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Datasets Mentioned

BETA
GTX80493

Methods Mentioned

BETA
gene knockdown
biopsy
PCR
transfection
light microscopy
fluorescence imaging
FRET

Software Mentioned

NIS
Origin Pro
OriginLab
LSM Image Examiner
Elements AR

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