Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia

Diabetes Care
P SpallarossaC Brunelli

Abstract

Sulfonylureas block the activation of vascular potassium-dependent ATP channels and impair the vasodilating response to ischcmia in nondiabetic individuals, but it is not know whether this occurs in type 2 diabetic patients under chronic treatment with these drugs. Glimepiride, a new sulfonylurea, apparently has no cardiovascular interactions. The aim of our study was to compare the effect of the widely used compound glibenclamide, the pancreas-specific glimepiride, and diet treatment alone on brachial artery response to acute forearm ischemia. Brachial artery examination was performed by a high-resolution ultrasound technique on 20 type 2 diabetic patients aged mean +/- SD) 67 +/- 2 years and on 18 nondiabetic patients matched for age, hypertension, and dislipidemia. Diabetic subjects underwent three separate evaluations at the end of each 8-week treatment period, during which they received glibenclamide, glimepiride, or diet alone according to crossover design. Scans were obtained before and after 4.5 min of forearm ischemia. Postischemic vasodilation and hyperemia were expressed as percent variations in vessel diameter and blood flow. Postischemic vasodilation and hyperemia were, respectively, 5.42 +/- 0.90 and 331 +/- 38% d...Continue Reading

References

Feb 1, 1992·Circulation Research·G J Gross, J A Auchampach
Dec 15, 1992·Biochimica Et Biophysica Acta·S J Ashcroft, F M Ashcroft
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Feb 14, 1995·European Journal of Pharmacology·E N KosmasS N Hussain
Sep 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K GeisenJ G Papp
Aug 26, 1998·Drugs·M J MacLeod, J McLay

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Citations

Jun 13, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N IhlemannP C Eskildsen
Feb 18, 2003·Fundamental & Clinical Pharmacology·Denis RavelEliete Bouskela
Apr 14, 2012·International Journal of Vascular Medicine·M MoerlandJ Burggraaf
Jul 27, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sandra J HamiltonGerald F Watts
Jul 29, 2004·Journal of Endocrinological Investigation·P SpallarossaC Brunelli

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