Sulfonylurea use and the risk of hospital readmission in patients with type 2 diabetes

BMC Endocrine Disorders
Pamela C HeatonS Rajpathak

Abstract

Hospital inpatient care for patients with diabetes was estimated to cost $76 billion in 2012. Substantial expense resulted from those patients having multiple hospitalizations. The objective was to compare the risk for diabetes-related hospital readmission in patients with type 2 diabetes treated with sulfonylureas (SUs) compared to those treated with other oral antihyperglycemic agents (AHAs). A retrospective cohort analysis was conducted using two-year panels, from 1999 to 2010, from the Medical Expenditure Panel Survey. The study included patients with type 2 diabetes taking an oral AHA who experienced a diabetes-related hospitalization. A Cox proportional hazard regression predicting time to readmission was used to estimate and compare the risks of readmission for SU-monotherapy versus other-AHA-monotherapy patients. Covariates included age, gender, marital status, cardiovascular disease, kidney disease, and eye disease, along with a propensity score to control for selection bias. The lack of clinical data on disease severity and progression limited our ability to estimate causal relationships between drug use and risk of hospital readmission. From 1999 to 2010, an estimated 13.5 million patients experienced a diabetes-rela...Continue Reading

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May 13, 2017·Current Medical Research and Opinion·Jenna CollinsElsie Allen
Apr 15, 2018·Journal of Diabetes·Zachary Bloomgarden, Yehuda Handelsman
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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

SAS
R

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