Sulfonylureas enhance in vivo the effectiveness of insulin in type 1 (insulin dependent) diabetes mellitus

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
A E PontiroliG Pozza

Abstract

Indirect evidence suggests that sulfonylureas, in addition to stimulating insulin release, exert additional effects at extrapancreatic levels which are of value in the management of type 2 diabetes. In order to characterize in vivo some of these effects, insulin sensitivity was studied in 9 type 1 diabetics with no residual insulin secretory activity, during treatment with chlorpropamide (250 mg b.i.d. for 8 days) and with glipizide (5 mg t.i.d. for 8 days). Employing the glucose clamp technique with the aid of an artificial pancreas (Biostator), glucose disposal during insulin infusion (0.1 U/kg in 60 min) was calculated by the amount of glucose required to keep the blood glucose at preinfusion levels. Chlorpropamide and glipizide administration was accompanied by a significant increase of the amount of glucose required to clamp blood glucose levels, while serum (free) insulin levels were superimposable during the different clamping studies. In the absence of endogenous insulin release, these data strongly suggest that the two sulfonylureas employed enhance in vivo the peripheral sensitivity to insulin. Further studies are required to indicate a preferential site of action (liver, muscle, adipose tissue) of sulfonylureas.

Citations

Oct 21, 2003·The Annals of Pharmacotherapy·Mary U Kabadi, Udaya M Kabadi
Apr 1, 1994·Diabetes/metabolism Reviews·A E PontiroliG Pozza
Jan 1, 1991·European Journal of Clinical Pharmacology·A E PontiroliG Pozza
Jan 2, 2001·Endocrine Reviews·S MatthaeiH U Häring
Jun 11, 1992·The Annals of Pharmacotherapy·J G GumsL R Reynolds
Nov 2, 1989·The New England Journal of Medicine·J E Gerich
Dec 1, 1987·The American Journal of Physiology·Y J YangR N Bergman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
U KellerW Berger
Bollettino della Società italiana di biologia sperimentale
F CapaniS Sensi
European Journal of Clinical Pharmacology
E Wåhlin-BollB Scherstén
© 2021 Meta ULC. All rights reserved