Sulfoquinovosylacylpropanediol is a novel potent radiosensitizer in prostate cancer

International Journal of Urology : Official Journal of the Japanese Urological Association
Yugo SawadaKazunari Tanabe

Abstract

To examine the effects of combined treatment with sulfoquinovosylacylpropanediol and X-ray irradiation on the remodeling of the prostate cancer microenvironment, including angiogenic and hypoxic characteristics. Human prostate cancer cells (DU145 and PC3) were implanted subcutaneously into the right hind legs of athymic nude mice. After the tumor volume reached 100-300mm(3) , 2mg/kg/day sulfoquinovosylacylpropanediol was given intravenously from day0 to day4, and cells were exposed to 4Gy X-ray irradiation on days0 and 3 (for a total of 8Gy). Tumors were fixed and stained for pathological analyses and immunohistochemical evaluations. To analyze vascular normalization, 60mg/kg pimonidazole dissolved in saline was injected intraperitoneally. Combined treatment with sulfoquinovosylacylpropanediol plus X-ray irradiation enhanced growth inhibition in DU145 xenografts. The tumor vessel density in DU145 cells significantly decreased after the combined treatment. Staining for αsmooth muscle actin in vessels was significantly increased. Pimonidazole staining, showing hypoxic lesions, was negative from 72h, but positive at 6 and 24h after the first combined treatment. In contrast, no enhancement of the microenvironment in PC3 xenografts ...Continue Reading

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Citations

Dec 23, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Takafumi YagisawaKazunari Tanabe
Apr 10, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Boyang Jason Wu
Apr 25, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuyoshi Miyata, Hideki Sakai
Mar 16, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Tatsushi RuikeKengo Sakaguchi
Oct 13, 2015·Scientific Reports·Jesus Izaguirre-CarbonellFumio Sugawara

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