Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.

FEBS Letters
Yasuhiro ShinkaiYoshito Kumagai

Abstract

Sulforaphane (SFN) is an activator of the transcription factor Nrf2, which plays a critical role in metabolism and excretion of xenobiotics. Exposure of primary mouse hepatocytes to SFN resulted in activation of Nrf2 and significant elevation of protein expressions responsible for excretion of arsenic into extracellular space. Pretreatment with SFN 24 h prior to arsenite exposure reduced not only arsenic accumulation in the cells but also cellular toxicity of this metalloid. Therefore, our findings indicate a potential function of SFN in reducing cellular arsenic levels, thereby diminishing arsenic toxicity.

References

Jan 18, 1989·Journal of the National Cancer Institute·L J GoldsteinG M Brodeur
Jan 1, 1993·Chemical Research in Toxicology·N ScottD E Carter
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D W LoeS P Cole
Jul 18, 1997·Biochemical and Biophysical Research Communications·J F Liang, T Akaike
Jan 16, 2002·The Journal of Biological Chemistry·Shan LinDavid J Thomas
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jed W FaheyAlain Lozniewski
Oct 2, 2002·FEBS Letters·Barry P Rosen
Nov 12, 2002·Environmental Health Perspectives·Miroslav StýbloDavid J Thomas
Nov 29, 2002·International Journal of Hygiene and Environmental Health·T W Gebel
May 15, 2003·Biochemical and Biophysical Research Communications·Junko AonoTetsuro Ishii
Apr 28, 2004·Free Radical Biology & Medicine·Ken ItohMasayuki Yamamoto
Sep 16, 2004·Archives of Toxicology·Seishiro HiranoAmjad Shraim
Sep 29, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kati-Sisko VellonenArto Urtti
Oct 13, 2004·Mutation Research·Mi-Kyoung KwakThomas W Kensler

❮ Previous
Next ❯

Citations

Aug 24, 2012·Archives of Toxicology·Dona SinhaAnupam Bishayee
Jan 27, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hemantkumar ChavanPartha Krishnamurthy
Apr 17, 2013·Molecular and Cellular Biology·Alexandria LauDonna D Zhang
Sep 28, 2006·Annual Review of Pharmacology and Toxicology·Yoshito Kumagai, Daigo Sumi
Jun 13, 2009·American Journal of Respiratory Cell and Molecular Biology·David J BlakeShyam Biswal
Feb 19, 2016·Journal of Biochemical and Molecular Toxicology·Eric J DitzelTodd D Camenisch
Jul 10, 2007·The Journal of Nutritional Biochemistry·Kristin E Harris, Elizabeth H Jeffery
Nov 29, 2012·Journal of Biochemical and Molecular Toxicology·Alexandria LauDonna D Zhang
Mar 30, 2016·Free Radical Biology & Medicine·Yingdong ZhuShengmin Sang
Oct 2, 2007·Biochemical and Biophysical Research Communications·Takashi ToyamaYoshito Kumagai
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shuang GaoBing Li
Nov 6, 2012·Biological & Pharmaceutical Bulletin·Yasuhiro Shinkai, Toshiyuki Kaji
Jun 4, 2010·The Journal of Toxicological Sciences·Yumi AbikoYoshito Kumagai
May 11, 2011·Free Radical Biology & Medicine·Swaran J S Flora
May 10, 2011·Free Radical Biology & Medicine·Matthew J KesicIlona Jaspers
Apr 17, 2013·Free Radical Biology & Medicine·Ryuhei HayashiKohji Nishida
Dec 3, 2014·World Journal of Pediatrics : WJP·Hong-Fang DingXiu-Li Ju
Jul 7, 2016·Oxidative Medicine and Cellular Longevity·Liu TongqiangDing Xiaoqiang
Jun 17, 2016·Toxicology and Applied Pharmacology·Yuji FuseMakoto Kobayashi
Aug 16, 2016·Molecular Nutrition & Food Research·Si Qin, De-Xing Hou
Jul 6, 2013·Analytical Chemistry·Kunka Mohanram RamkumarRamasamy Paulmurugan
Jan 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Palak ShahYu-Ying He
Jun 15, 2007·Toxicologic Pathology·Lauren M Aleksunes, José E Manautou
Dec 1, 2017·Antioxidants & Redox Signaling·Stephen Jun Fei ChongShazib Pervaiz
Jun 27, 2013·Cellular and Molecular Life Sciences : CMLS·Hadi DigalehFariba Khodagholi
Jan 30, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hideo TakakusaKenichi Sudo
Feb 13, 2020·International Journal of Molecular Sciences·Yuka EndoMakoto Kobayashi
Jul 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shu-Hua YangJian-Bin He

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.