Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems.

Archives of Pharmacal Research
Mohammad M KamalSami Nazzal

Abstract

Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against multiple cancer types including pancreatic, prostate, breast, lung, cervical, and colorectal cancers. Sulforaphane exerts its therapeutics action by a variety of mechanisms, such as by detoxifying carcinogens and oxidants through blockage of phase I metabolic enzymes, and by arresting cell cycle in the G2/M and G1 phase to inhibit cell proliferation. The most striking observation was the ability of sulforaphane to potentiate the activity of several classes of anticancer agents including paclitaxel, docetaxel, and gemcitabine through additive and synergistic effects. Although a good number of reviews have reported on the mechanisms by which sulforaphane exerts its anticancer activity, a comprehensive review on the synergistic effect of sulforaphane and its delivery strategies is lacking. Therefore, the aim of the current review was to provide a summary of the studies that have been reported on the activity enhancement effect of sulforaphane in combination with other anticancer therapies. Also provided is a summary of the strategies that have been developed for the delivery of sulfora...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H J ProchaskaP Talalay
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangG H Posner
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J W Fahey, P Talalay
Dec 20, 1999·Journal of Agricultural and Food Chemistry·Y JinC T Ho
Jan 31, 2002·Annual Review of Medicine·Michael M Gottesman
Jan 18, 2003·Cellular and Molecular Life Sciences : CMLS·C FimognariP Hrelia
Oct 13, 2004·Mutation Research·Young-Sam KeumA N Tony Kong
Mar 15, 2005·The Journal of Biological Chemistry·Shivendra V SinghAnna Herman-Antosiewicz
May 21, 2005·International Journal of Cancer. Journal International Du Cancer·Victoria YoxallCostas Ioannides
Nov 23, 2005·European Journal of Medicinal Chemistry·Robert M MoriartyOm Prakash
Mar 8, 2006·Cancer Letters·Melinda C Myzak, Roderick H Dashwood
Dec 1, 2006·Mutation Research·Carmela Fimognari, Patrizia Hrelia
Mar 10, 2007·Carcinogenesis·Brian S CornblattKala Visvanathan
Mar 31, 2007·Cellular and Molecular Life Sciences : CMLS·N JugeM Traka
Aug 29, 2007·Acta Pharmacologica Sinica·Yuesheng Zhang, Li Tang
May 28, 2008·Cancer Letters·John D ClarkeEmily Ho
Jan 31, 2009·Nature Reviews. Drug Discovery·Jia JiaYu Zong Chen
Nov 20, 2009·International Journal of Pharmaceutics·D P DoM J D'Souza
Oct 14, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Georgios KallifatidisIngrid Herr
Mar 9, 2011·Integrative Cancer Therapies·Arif HussainChhavi Sharma
May 30, 2012·Biochimica Et Biophysica Acta·Aleksandra WiczkAnna Herman-Antosiewicz
Apr 25, 2013·Drug Development and Industrial Pharmacy·Stephen J FranklinPaul B Myrdal
May 1, 2013·International Journal of Nanomedicine·Gerald G EnriquezDuc P Do
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Arif HussainChhavi Sharma

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Citations

Mar 13, 2021·Free Radical Biology & Medicine·Qi Wang, Yongping Bao
Jun 5, 2021·Nutrition and Cancer·Mustafa B A Djamgoz, Valerie Jentzsch
Jun 27, 2021·Pharmacology & Therapeutics·Danielle Baribeau, Evdokia Anagnostou
Jul 3, 2021·Free Radical Biology & Medicine·Kyung-Soo ChunYoung-Joon Surh

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