Sulfoxide-mediated oxidative cross-coupling of phenols.

Chemical Science
Zhen HeDavid J Procter

Abstract

A metal-free, oxidative coupling of phenols with various nucleophiles, including arenes, 1,3-diketones and other phenols, is reported. Cross-coupling is mediated by a sulfoxide which inverts the reactivity of the phenol partner. Crucially, the process shows high selectivity for cross-versus homo-coupling and allows efficient access to a variety of aromatic scaffolds including biaryls, benzofurans and, through an iterative procedure, aromatic oligomers.

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Citations

Apr 16, 2020·Chemical Communications : Chem Comm·Akihiro KobayashiSuguru Yoshida
Jul 30, 2021·Chemistry : a European Journal·Tomoyuki Yanagi, Hideki Yorimitsu
Aug 24, 2021·The Journal of Organic Chemistry·Chandrahas TarigopulaRengarajan Balamurugan

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