Sulfur dioxide improves endothelial dysfunction by downregulating the angiotensin II/AT1 R pathway in D-galactose-induced aging rats

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Jing DaiAijie Zhang

Abstract

The aim of this study was to investigate the protective effects of sulfur dioxide (SO2) on the endothelial function of the aorta in D-galactose (D-gal)-induced aging rats. Sprague Dawley rats were randomized into a D-gal group, a D-gal + SO2 group and a control group, then injected with D-gal, D-gal + SO2 donor or equivalent volumes of saline, respectively, for 8 consecutive weeks. After 8 weeks, the mean arterial pressure was significantly increased in the D-gal group, but was lowered by SO2. SO2 significantly ameliorated the endothelial dysfunction induced by D-gal treatment. The vasorelaxant effect of SO2 was associated with the elevated nitric oxide levels and upregulated phosphorylation of endothelial nitric oxide synthase. In the D-gal group, the concentration of angiotensin II in the plasma was significantly increased, but was decreased by SO2. Moreover, levels of vascular tissue hydrogen peroxide (H2O2) and malondialdehyde were significantly lower in SO2-treated groups than those in the D-gal group. Western blot analysis showed that the expressions of oxidative stress-related proteins (the angiotensin II type 1 receptor (AT1R), and nicotinamide adenine dinucleotide phosphate oxidase subunits) were increased in the D-gal...Continue Reading

References

Feb 7, 2009·The Journal of Clinical Investigation·Ariela BenigniGiuseppe Remuzzi
Jul 25, 2009·Free Radical Biology & Medicine·David I Brown, Kathy K Griendling
Jan 19, 2010·Journal of Molecular and Cellular Cardiology·Mingyi WangAjay M Shah
Jun 15, 2010·Mini Reviews in Medicinal Chemistry·Die LiuJunbao Du
Aug 3, 2010·European Journal of Pharmacology·Junling LiZiqiang Meng
Sep 8, 2010·Cardiovascular Research·Elena M V de CavanaghLeón Ferder
Aug 16, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Edward P Weiss, Luigi Fontana
Mar 1, 2012·Aging·Pat Monaghan
Dec 19, 2012·Antioxidants & Redox Signaling·Dler Faieeq Darweesh MahmoodMustapha Rouis
Nov 5, 2014·Hypertension·Zhongjie Sun
Dec 1, 2014·Advances in Physiology Education·Jessica R Santos-ParkerDouglas R Seals
May 3, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Elena M V de CavanaghLeón Ferder
Feb 4, 2016·Oxidative Medicine and Cellular Longevity·Yaqian HuangHongfang Jin
Feb 26, 2016·International Journal of Molecular Sciences·Zhenzhen LiHongfang Jin
Oct 22, 2016·Mechanisms of Ageing and Development·Carla ReginaGiovanni Ruvolo
May 21, 2016·Oxidative Medicine and Cellular Longevity·Hye Eun YoonBum Soon Choi
Jun 23, 2016·Aging and Disease·Haiping ZhaoYumin Luo
Oct 11, 2016·Oxidative Medicine and Cellular Longevity·Jia LiuJunbao Du
Jul 29, 2017·Journal of the American Heart Association·Kazushi UnedaKouichi Tamura
Nov 14, 2017·Experimental Gerontology·Thazin ShweSiriporn C Chattipakorn
Feb 16, 2018·European Heart Journal·Giovanni G Camici, Luca Liberale

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Methods Mentioned

BETA
protein assay
electrophoresis
MDA

Software Mentioned

SPSS

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