Nov 5, 2018

Sulfur reduction coupling with anaerobic ammonium oxidation drives proto-anabolic networks

BioRxiv : the Preprint Server for Biology
Peng BaoHu Li

Abstract

The geochemical energy that drives the transition from non-life to life is as yet unknown. Here we show that thiosulfate/sulfate reduction coupling with anaerobic ammonium oxidation (Sammox), could provide the primordial redox equivalents and energy for prebiotic proto-anabolic networks, the reductive acetyl-CoA pathway combined with incomplete reductive tricarboxylic acid (rTCA) cycle, reductive amination and pyrrole synthesis. Fe-S mineral catalysis and thiols/thioesters as energy couplers enhance the efficiency of prebiotic proto-anabolic networks in thiosulfate-fueled Sammox reaction systems under hydrothermal conditions. Results implied that thiosulfate-fueled Sammox should be the primordial reaction driving the construction of proto-anabolic networks rather than sulfate-fueled Sammox, as it could be catalyzed, and also sulfate would have been severely limiting in ancient oceans. To confirm our findings, we isolated and identified a mixtrophic Sammox bacterium, Ralstonia thioammoniphilus GX3-BWBA, which prefer thiosulfate to sulfate. Genomic analysis of R. thioammoniphilus GX3-BWBA implied that this ancient metabolism in modern microbes should contain two stages according to ammonium transformation, -oxidation of ammonium ...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Base
Biochemical Pathway
Transformation, Genetic
Bacillus sp. R
Anabol
Genome
Metabolic Networks
Prebiotics
Anaerobic Ammonium Oxidation

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