Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis

BMC Cancer
Angelo Pietro FemiaGiovanna Caderni

Abstract

Recently, we showed that Sulindac (SU; 320 ppm) reduces precancerous lesions in the colon of Pirc rats, mutated in the Apc gene. Surprisingly, previous data in Apc-mutated mice showed that SU, with reported efficacy in Familial Adenomatous Polyposis (FAP), increases colon carcinogenesis. Therefore, we assessed the effect of SU 320 ppm in a long-term carcinogenesis experiment in Pirc rats. Moreover, since side effects of SU hamper its chronic use and a combination of drugs could be more effective and less toxic than single agents, we also studied whether two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis Pirc rats were fed an AIN76 diet containing SU, DIM and CUR and sacrificed at 8 months of age to measure intestinal tumours. Apoptosis and proliferation in the normal colon mucosa, as well as gene expression profile were studied Colon tumours were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone. Total tumours (colon and small intestine) were reduced by SU (80 and 320 ppm) and by DIM and CUR. Ap...Continue Reading

References

May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
May 1, 1993·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·A LlompartJ Riera
Sep 30, 1995·Annals of the New York Academy of Sciences·C V RaoB S Reddy
Apr 5, 2002·The New England Journal of Medicine·Francis M GiardielloStanley R Hamilton
Jul 17, 2004·Carcinogenesis·Gavin P Collett, Frederick Charles Campbell
Aug 9, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Denis E Corpet, Fabrice Pierre
Jun 8, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marcia Cruz-CorreaFrancis M Giardiello
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·James M Amos-LandgrafWilliam F Dove
Apr 24, 2007·Cancer Letters·Jeremy James Johnson, Hasan Mukhtar
Jul 7, 2007·Sub-cellular Biochemistry·Bandaru S Reddy
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Apr 9, 2008·Gastroenterology·Nadir Arber, Bernard Levin
Jan 14, 2009·Cancer Prevention Research·Angelo Pietro FemiaGiovanna Caderni
Apr 1, 2009·Inflammatory Bowel Diseases·Yoon Hee KimJin-Kyung Kim
Oct 29, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gang XuKeli Tian
Aug 19, 2010·Cancer Prevention Research·Emily J GreenspanDaniel W Rosenberg
Oct 7, 2011·International Journal of Cancer. Journal International Du Cancer·Angelo Pietro FemiaGiovanna Caderni
Nov 30, 2011·Best Practice & Research. Clinical Gastroenterology·Brian Kim, Francis M Giardiello
Jan 22, 2013·Biochimica Et Biophysica Acta·Maged Zeineldin, Kristi L Neufeld
Feb 19, 2013·Gastroenterology·Mary Kay WashingtonWilliam F Dove
Mar 8, 2013·Cancer Prevention Research·Wungki ParkDong M Shin
May 8, 2013·International Journal of Cancer. Journal International Du Cancer·Angelo Pietro FemiaGiovanna Caderni
Sep 27, 2014·International Journal of Cancer. Journal International Du Cancer·Angelo Pietro FemiaGiovanna Caderni
Oct 8, 2014·Disease Models & Mechanisms·Amy A IrvingJames M Amos-Landgraf

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Citations

Jun 25, 2016·Journal of the American Chemical Society·Braja Gopal DasBas de Bruin
Oct 19, 2016·International Journal of Cancer. Journal International Du Cancer·Furkan U ErtemRoderick H Dashwood
May 9, 2018·Journal of Cellular Physiology·Reyhaneh Moradi MarjanehMajid Khazaei
Dec 5, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Changhong YunMing Hu
Aug 12, 2018·International Journal of Molecular Sciences·Altaf MohammedChinthalapally V Rao
Nov 11, 2019·Life Sciences·Chelliah SelvamRamasamy Thilagavathi

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