Sulodexide in the treatment of chronic venous disease

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
Giuseppe Maria Andreozzi

Abstract

Chronic venous disease encompasses a range of venous disorders, including those involving the lower limbs resulting from venous hypertension. The spectrum of chronic venous disease signs and symptoms shows variable severity, ranging from mild (aching, pain, and varicose veins) to severe (venous ulcers). The pathophysiology of chronic venous disease is characterized by venous hypertension, which triggers endothelial dysfunction and inflammation leading to microcirculatory and tissue damage, and eventually to varicose veins and venous ulcers. Sulodexide is an orally active mixture of glycosaminoglycan (GAG) polysaccharides with established antithrombotic and profibrinolytic activity. The agent is used in the treatment of a number of vascular disorders with increased risk of thrombosis, including intermittent claudication, peripheral arterial occlusive disease and post-myocardial infarction. Sulodexide differs from heparin because it is orally bioavailable and has a longer half-life and a smaller effect on systemic clotting and bleeding. An increasing body of preclinical evidence shows that sulodexide also exerts anti-inflammatory, endothelial-protective, and pleiotropic effects, supporting its potential efficacy in the treatment ...Continue Reading

References

Jul 1, 1991·The British Journal of Surgery·S R BakerP J Thompson
Jun 18, 1983·British Medical Journal·N L Browse
Feb 1, 1994·The British Journal of Surgery·O NelzénA Lindhagen
Sep 1, 1996·The Journal of International Medical Research·A GaddiS Nascetti
May 14, 1998·Seminars in Thrombosis and Hemostasis·F A Ofosu
Jun 4, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M SaharayP D Coleridge Smith
Dec 2, 1999·Angiology·G ScondottoL Martini
Sep 16, 2000·Annals of Vascular Surgery·S TakaseG Schmid-Schönbein
Jul 3, 2002·European Heart Journal·S CoccheriUNKNOWN Arterial Arm of the Suavis (Sulodexide Arterial Venous Italian Study) group
Sep 27, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M H Howlader, P D Smith
Jun 5, 2004·BMJ : British Medical Journal·Deborah A SimonCharles N McCollum
Jul 20, 2004·Drugs·Douglas Jacoby, Emile R Mohler
Sep 15, 2004·The Journal of Pharmacology and Experimental Therapeutics·D Adam LauverBenedict R Lucchesi
Dec 29, 2004·Journal of Vascular Surgery·Bo EklöfUNKNOWN American Venous Forum International Ad Hoc Committee for Revision of the CEAP Classification
Jul 11, 2006·British Journal of Haematology·Susan R Kahn
Aug 2, 2006·Treatments in Endocrinology·Cataldo Abaterusso, Giovanni Gambaro
Aug 4, 2006·The New England Journal of Medicine·John J BerganBo Eklof
Jan 12, 2007·Cardiovascular Drug Reviews·D Adam Lauver, Benedict R Lucchesi
Jan 30, 2007·European Journal of Pharmacology·Jacek BorawskiMichal Mysliwiec
Jan 18, 2008·Journal of Vascular Surgery·Mark H MeissnerSeshadri Raju
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Joanna GozdzikiewiczMichal Mysliwiec
Jan 8, 2008·Journal of Vascular Surgery·John J BerganGeert W Schmid-Schönbein
Jan 12, 2008·Blood Purification·Jacek KarońAndrzej Breborowicz
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Jul 4, 2008·Physiological Research·V KristováA Kurtanský
Feb 17, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Marta CiszewiczAndrzej Breborowicz
Sep 5, 2009·Advances in Medical Sciences·J BorawskiM Mysliwiec
Dec 4, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M Perrin, A A Ramelet
Sep 1, 1995·Clinical Drug Investigation·G L MessaT Di Perri

❮ Previous
Next ❯

Citations

Jan 7, 2014·Drug Design, Development and Therapy·Sergio Coccheri, Ferdinando Mannello
Jun 19, 2016·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Joseph D RaffettoFerdinando Mannello
Mar 18, 2015·British Journal of Clinical Pharmacology·Bernhard F BeckerDaniel Chappell
Apr 30, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C WittensUNKNOWN European Society for Vascular Surgery
Jul 12, 2016·Advances in Therapy·Nizar ElleuchUNKNOWN CVD study investigators
Jul 28, 2016·Biochimica Et Biophysica Acta·Daniela LigiFerdinando Mannello
Aug 2, 2016·Biochimica Et Biophysica Acta·Daniela LigiFerdinando Mannello
Jun 4, 2015·Phlebology·Lavanya VaratharajanAlun Huw Davies
Dec 15, 2015·Phlebology·Sergio Coccheri, Angelo A Bignamini
Jun 3, 2016·The Cochrane Database of Systematic Reviews·Bin WuTing Xu
Jun 7, 2018·Phlebology·Costantino Davide CritelloRaffaele Serra
Jan 29, 2020·Advances in Therapy·Angelo A Bignamini, Jiří Matuška
Dec 18, 2020·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·Iu L ShevchenkoT Iu Cherniago
Feb 10, 2020·The American Journal of Pathology·Zaid AbassiSamuel N Heyman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Drug Design, Development and Therapy
Sergio Coccheri, Ferdinando Mannello
Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society
Elaine H FriedbergIan D Graham
European Journal of Pharmacology
Jacek BorawskiMichal Mysliwiec
© 2022 Meta ULC. All rights reserved