PMID: 6113021May 16, 1981Paper

Sulphasalazine retention enemas in ulcerative colitis: a double-blind trial

British Medical Journal
K R PalmerC D Holdsworth

Abstract

Thirty-four patients with ulcerative colitis completed a double-blind assessment comparing the efficacy of two weeks of treatment with nightly retention enemas containing 3 g sulphasalazine or placebo. Symptom grading, sigmoidoscopic appearance, rectal biopsy specimens, and diary records were used to assess benefit and side effects. The active drug conferred significant benefit compared with placebo as shown by several criteria, but this benefit was confined to patients not already taking sulphasalazine by mouth. Overall assessment showed improvement in 11 of the 16 patients (70%) given the active treatment but in only two of the 18 (11%) given placebo. No side effects attributable to the drug were observed, even in patients previously intolerant to oral preparations. The logical therapeutic role of sulphasalazine enemas in ulcerative colitis would appear to be in patients who experience side effects such as nausea, abdominal discomfort, or headaches when taking the drug by mouth.

References

Jul 1, 1972·Clinical Pharmacology and Therapeutics·H Schröder, D E Campbell
Nov 1, 1966·The American Journal of Digestive Diseases·R Wright, S R Truelove
Jan 10, 1981·British Medical Journal·C D Holdsworth
Sep 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·N H RoweT J Petrick

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Citations

Feb 1, 1989·Diseases of the Colon and Rectum·F NagyV Varro
Nov 1, 1984·Postgraduate Medical Journal·J E Lennard-Jones
Oct 16, 2007·Digestive Diseases and Sciences·Sagar GarudCiaran P Kelly
Mar 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·M A McFaddenD F Kirby
Oct 1, 1995·Inflammatory Bowel Diseases·A Bitton, M A Peppercorn
Sep 9, 2017·The Cochrane Database of Systematic Reviews·Vipul JairathBrian G Feagan
Jan 22, 2010·The Cochrane Database of Systematic Reviews·John K MarshallE Jan Irvine
Oct 1, 1982·Scandinavian Journal of Gastroenterology·W KruisG Paumgartner
Jul 12, 2020·Journal of Crohn's & Colitis·Femke CrouwelNanne K de Boer
Oct 1, 1989·Scandinavian Journal of Gastroenterology·S A RileyV Mani
Mar 1, 1997·Baillière's Clinical Gastroenterology·F Richter, W Scheppach
Mar 1, 1992·Baillière's Clinical Gastroenterology·R J Polson, J J Misiewicz

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