PMID: 2567049Jan 1, 1989Paper

Sulphasalazine versus penicillamine in the treatment of rheumatoid arthritis

Rheumatology International
G J CarrollL M Tinsley


Fifty-four patients with rheumatoid arthritis were randomized to either sulphasalazine or D-penicillamine in order to compare the short- and long-term efficacy of these two agents in the treatment of rheumatoid arthritis. Decisive improvement was observed in both treatment groups over a 1 year period. Side effects were common in both groups and accounted for termination of therapy in 11 patients during the first year. Radiological deterioration was evident in both treatment groups. A trend toward greater radiological deterioration was observed in patients receiving sulphasalazine, but this was not statistically significant. Only 11 of the 38 patients who completed 1 year of therapy were continuing to take the same drug 5 years later. Eight patients were continuing D-penicillamine and three were still taking sulphasalazine. Among the patients who completed 1 year of therapy, treatment was subsequently terminated because of loss of effective disease control in a significantly higher proportion of patients receiving sulphasalazine (P less than 0.01). The radiological data and the latter observations suggest that D-penicillamine may be a more effective agent for long-term treatment.


Jun 1, 1978·Agents and Actions·B McConkeyL Walsh
Dec 1, 1985·Annals of the Rheumatic Diseases·T PullarH A Capell
Dec 1, 1986·Arthritis and Rheumatism·R S PinalsB Hepburn
May 1, 1987·Annals of the Rheumatic Diseases·T PullarH A Capell
Nov 1, 1974·Annals of the Rheumatic Diseases·E C HuskissonJ A Wojtulewski
Aug 26, 1972·British Medical Journal·H Schröder
Feb 16, 1980·British Medical Journal·B McConkeyL Walsh
Jun 1, 1984·Annals of the Rheumatic Diseases·K A Grindulis, B McConkey
Dec 1, 1984·Annals of Internal Medicine·B AmorF Delrieu
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman

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