Sulphated polysaccharide isolated from Sargassum vulgare: Characterization and hypolipidemic effects

Carbohydrate Polymers
Rihab Ben Abdallah KolsiKarima Belghith

Abstract

A sulphated polysaccharide from brown algae Sargassum vulgare (SVSP) was extracted and examined with respect to chemical, structural characterization and hypolipidemic effects. SVSP consisted mainly of sulphate and total sugars with low levels of lipids and proteins. Its structure was studied by nuclear magnetic resonance (RMN), gas chromatography-mass spectrometry (GC-MS), infra-red spectroscopic, differential scanning calorimetry and X-ray diffraction analysis. Allowing us therefore to revealed that SVSP was composed of glucose, rhamnose, xylose, galactose, mannose and arabinose with XRD pattern that was typical for a semi-crystalline polymer and complexities of the spectra reflected its homogeneous structure. The administration of SVSP to obese rats is effective in lowering the body weight and inhibiting the lipase activity leading to notable regulation of lipid profile, increasing the activities of antioxidant enzymes, limiting lipid peroxidation; and protects liver-kidney functions proved by a decrease in the levels of toxicity parameters in blood, confirmed by histological study.

Citations

May 10, 2019·International Journal of Biological Macromolecules·Hajer BougatefAssaâd Sila
Aug 24, 2021·The International Journal of Biochemistry & Cell Biology·Min CaiWeihong Zhong
Nov 26, 2021·Journal of Food Biochemistry·Sisheng ZhangHongxia Cui

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