Sulphated zirconia as an eco-friendly catalyst in acylal preparation under solvent-free conditions, acylal deprotection assisted by microwaves, and the synthesis of anhydro-dimers of o-hydroxybenzaldehydes.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Laura Nadxieli Palacios-GrijalvaGuillermo E Negrón-Silva

Abstract

A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-dimers was observed. The deprotection reaction involves microwave (MW) exposure of diluted reactants in the presence of solid sulphated zirconia (SZ) catalyst that can be easily recovered and reused. The sulphated zirconia was recycled several times without any loss of activity.

Citations

Jan 25, 2011·Nature Reviews. Cancer·Sabine S LangeRichard D Wood
Mar 17, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Celia Xochitl Hernández-ReyesGuillermo E Negrón-Silva

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Methods Mentioned

BETA
X ray
acetylation

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