Sulpiride induced torsade de pointes

International Journal of Cardiology
Bien-Hsien HuangChung-Yin Chen

Abstract

Antipsychotic agents are known to be associated with a long QT interval and torsade de pointes. We report a 69 year old female who suffered from a syncopal attack at a psychiatric hospital and was referred to our center. Torsade de pointes with a long QT interval (QTc=680 ms) was observed on the 12 lead ECG in the emergency department and intensive care unit. A careful drug history revealed that sulpiride was the culprit agent. After stopping the medication, the QT interval returned to normal (420 ms). The patients taking sulpiride should be closely monitored, especially when it is used in combination with other antidepressant agents.

References

Feb 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A MucciM Maj
Jun 9, 1999·The American Journal of Psychiatry·J L Levenson
Jul 20, 2002·Journal of Cardiovascular Pharmacology·Atsushi SugiyamaKeitaro Hashimoto

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Citations

Apr 10, 2010·Expert Opinion on Drug Safety·Pamela L SmithburgerSandra L Kane-Gill
Oct 28, 2009·The American Journal of Emergency Medicine·Jia-How ChangCheng-Chung Fang
Jan 15, 2008·International Journal of Cardiology·P NisseM Mathieu-Nolf
Jun 24, 2009·International Journal of Toxicology·Hyang-Ae LeeEun-Joo Kim
Nov 26, 2009·Drugs & Aging·W Victor R ViewegAnand K Pandurangi
Dec 18, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Su-Hyun Jo, So-Young Lee
Nov 25, 2011·Deutsches Ärzteblatt International·Katharina Wenzel-SeifertEkkehard Haen

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