Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study

The Journal of Clinical Psychiatry
N VerdoliniBRIDGE-II-Mix Study Group

Abstract

This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR). In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the context of bipolar I or II disorder (BD-I, BD-II, respectively) or major depressive disorder, were enrolled between June 2009 and July 2010. Patients with (MDE-AL, n = 694) and without (MDE-noAL, n = 1,883) AL and with (MDE-MR, n = 1,035) or without (MDE-noMR, n = 1,542) MR were compared through χ² test or Student t test. Stepwise backward logistic regression models, respectively testing AL and MR as the dependent variable, were performed to differentiate the 2 clinical constructs. AL was positively associated with BD-I (P < .001) and BD-II (P < .001), with DSM-5 mixed (DSM-5-MXS) (P < .001) and atypical (DSM-5-AD) features (P < .001) and negatively associated with MDD (P < .001). In the logistic regression models, MR was the variable most significantly associated with AL and vice versa (P < .001 for both). AL was positively associated...Continue Reading

Citations

Nov 30, 2019·The International Journal of Neuropsychopharmacology·Raffaella CalatiIgor Galynker
Jul 14, 2020·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Evyn M PetersRudy Bowen
Sep 23, 2020·Bipolar Disorders·Maria Antonietta FurioUNKNOWN BRIDGE-II-Mix Study Group
Nov 5, 2021·International Journal of Bipolar Disorders·Margrethe Collier HøeghTrine Vik Lagerberg

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