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Sumatriptan inhibits TRPV1 channels in trigeminal neurons

Headache

Feb 1, 2012

Miles Steven EvansLouis S Premkumar

Abstract

To understand a possible role for transient potential receptor vanilloid 1 (TRPV1) ion channels in sumatriptan relief of pain mediated by trigeminal nociceptors. TRPV1 channels are expressed in small nociceptive sensory neurons. In dorsal root ganglia, TRPV1-containing nociceptors media...read more

Mentioned in this Paper

Entire Trigeminal Ganglion
Immunohistochemistry
Blood Vessel
Neurons
Inflammatory Pain
Brain
Action Potentials
Carbocyanines
Synaptic Transmission
PDZK1 gene
1
40
Paper Details
References
  • References34
  • Citations20
1234
  • References34
  • Citations20
12

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Sumatriptan inhibits TRPV1 channels in trigeminal neurons

Headache

Feb 1, 2012

Miles Steven EvansLouis S Premkumar

PMID: 22289052

DOI: 10.1111/j.1526-4610.2011.02053.x

Abstract

To understand a possible role for transient potential receptor vanilloid 1 (TRPV1) ion channels in sumatriptan relief of pain mediated by trigeminal nociceptors. TRPV1 channels are expressed in small nociceptive sensory neurons. In dorsal root ganglia, TRPV1-containing nociceptors media...read more

Mentioned in this Paper

Entire Trigeminal Ganglion
Immunohistochemistry
Blood Vessel
Neurons
Inflammatory Pain
Brain
Action Potentials
Carbocyanines
Synaptic Transmission
PDZK1 gene
1
40

Similar Papers Found In These Feeds

Molecular Organization of Synapses

This feed focuses on the molecular organization of synapses between two nerve cells, synaptic signal transduction, and synaptic vesicles. Here is the latest research on organization of synapses.

Formation of Synapses and Circuits

Synapses are crucial for the transmission of information within neural circuits. These specialized intercellular junctions are the basis for the formation of complex networks. Formation of these synapses involve numerous steps that are essential for transmission of information. Here is the latest research on formation of synapses and circuits.

Related Papers

Brain Research

Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat

Brain ResearchSeptember 4, 2007
Toshihiko ShimizuNorihiro Suzuki
Paper Details
References
  • References34
  • Citations20
1234
  • References34
  • Citations20
12
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