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SumHer better estimates the SNP heritability of complex traits from summary statistics

Nature Genetics

Dec 5, 2018

Doug Speed, David J Balding

Abstract

We present SumHer, software for estimating confounding bias, SNP heritability, enrichments of heritability and genetic correlations using summary statistics from genome-wide association studies. The key difference between SumHer and the existing software LD Score Regression (LDSC) is th...read more

Mentioned in this Paper

Computer Software
Genome-Wide Association Study
Study
Genome
Computer Programs and Programming
Quantitative Trait, Heritable
Inheritance Patterns
Regression Analysis
Analysis
Genetic Predisposition to Disease
159
89
1
Paper Details
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  • References51
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SumHer better estimates the SNP heritability of complex traits from summary statistics

Nature Genetics

Dec 5, 2018

Doug Speed, David J Balding

PMID: 30510236

DOI: 10.1038/s41588-018-0279-5

Abstract

We present SumHer, software for estimating confounding bias, SNP heritability, enrichments of heritability and genetic correlations using summary statistics from genome-wide association studies. The key difference between SumHer and the existing software LD Score Regression (LDSC) is th...read more

Mentioned in this Paper

Computer Software
Genome-Wide Association Study
Study
Genome
Computer Programs and Programming
Quantitative Trait, Heritable
Inheritance Patterns
Regression Analysis
Analysis
Genetic Predisposition to Disease
159
89
1

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  • Citations6
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  • References51
  • Citations6
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