PMID: 29770073May 18, 2018Paper

Summary of the NACI Update on the Recommended Use of Hepatitis B Vaccine

Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada
B HenryNational Advisory Committee on Immunization (NACI)

Abstract

Infant and adolescent hepatitis B (HB) immunization programs have been successfully implemented in all Canadian provinces and territories since the 1990s. Following the introduction of universal immunization programs, the incidence of HB has decreased in all age groups. However, the duration of protection against chronic infection, as measured by preserved T- and B-cell memory, remains unknown. To review the evidence on long-term protection against HB in adolescents who received routine immunization in infancy, determine the level of risk of HB infection in Canadians with diabetes and assess the timing of re-vaccination of individuals with immunocompromising conditions. The National Advisory Committee on Immunization (NACI) Hepatitis Working Group reviewed key questions and performed an evidence review and synthesis. In consideration of the burden of illness to be prevented, the target population and issues related to safety, immunogenicity, efficacy and effectiveness of the vaccine, the group proposed recommendations for vaccine use to NACI. All evidence was rated and summarized in tables. NACI approved specific evidence-based recommendations and elucidated the rationale and relevant considerations in the Statement update. In ...Continue Reading

Citations

Dec 24, 2020·Nature Reviews. Immunology·Andrew J Pollard, Else M Bijker

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