PMID: 29769963Apr 20, 2015Paper

Summary of the National Advisory Committee on Immunization's Update on quadrivalent meningococcal vaccines available in Canada

Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada
B Henry, National Advisory Committee on Immunization

Abstract

Invasive meningococcal disease (IMD) has an overall mortality of approximately 10% and up to 35% of survivors may experience long term sequelae. Canada's National Advisory Committee on Immunization (NACI) recommends immunization with a quadrivalent conjugate meningococcal vaccine of individuals who are at increased risk of IMD due to an underlying medical condition or have a high risk of exposure to N. meningitidis. Use of a conjugate vaccine, either monovalent or quadrivalent, is recommended for a routine adolescent booster dose at around 12 years of age. To review and update the evidence on the use of quadrivalent (serogroups A, C, Y and W-135) conjugate meningococcal vaccines and vaccination schedules used in Canada following the approval of a new quadrivalent meningococcal vaccine conjugated to the tetanus toxoid (Men-C-ACYW-TT, Nimenrix™). NACI reviewed the knowledge synthesis performed by the Meningococcal Working Group, including information on the IMD burden of disease; safety, immunogenicity, efficacy and effectiveness of the new vaccine; currently used vaccine schedules; and other aspects of the overall immunization strategy. Following the review of evidence, NACI voted on specific recommendations. A total of 21 studi...Continue Reading

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