Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen

Phytotherapy Research : PTR
D HainesA Tosaki

Abstract

In this study, combinations of Ginkgo biloba leaf extract (EGb761) plus the carotenoid antioxidant astaxanthin (ASX) and vitamin C were evaluated for a summative dose effect in the inhibition of asthma-associated inflammation in asthmatic guinea-pigs. Ovalbumin-sensitized Hartley guinea-pigs challenged with ovalbumin aerosol to induce asthma, were administered EGb761, ASX, vitamin C or ibuprofen. Following killing, bronchoalveolar lavage (BAL) fluid was evaluated for inflammatory cell infiltrates and lung tissue cyclic nucleotide content. Each parameter measured was significantly altered to a greater degree by drug combinations, than by each component acting independently. An optimal combination was identified that included astaxanthin (10 mg/kg), vitamin C (200 mg/kg) and EGb761 (10 mg/kg), resulting in counts of eosinophils and neutrophils each 1.6-fold lower; macrophages 1.8-fold lower, cAMP 1.4-fold higher; and cGMP 2.04-fold higher than levels in untreated, asthmatic animals (p < 0.05). In conclusion, EGb761, ASX and vitamin C are shown here to interact summatively to suppress inflammation with efficacy equal to or better than ibuprofen, a widely used non-steroidal antiinflammatory drug (NSAID). Such combinations of non-to...Continue Reading

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Citations

Jan 10, 2014·Marine Drugs·Ranga Rao AmbatiRavishankar Gokare Aswathanarayana
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Marcela Hernández-OrtegaHugo Necoechea-Mondragón
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Nov 28, 2014·Cell Stress & Chaperones·Fadia F MahmoudDavid D Haines
Apr 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Evelin CsepanyiIstvan Bak
Jun 26, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xingcai ZhangXianhai Chen
Jan 6, 2011·Molecular Nutrition & Food Research·Jian-Ping YuanJiang-Hai Wang
Jan 27, 2011·Anatomy & Cell Biology·Young-Joo JeongYoung-Il Hwang
Nov 13, 2020·Advances in Nutrition·Junrui Cheng, Abdulkerim Eroglu
Sep 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jianbin BiJingyao Zhang
Dec 24, 2020·International Journal of Molecular Sciences·Donald David Haines, Arpad Tosaki

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