Jan 19, 2010

SUMO--a post-translational modification with therapeutic potential?

Current Opinion in Pharmacology
Chang-Hoon Woo, Jun-ichi Abe

Abstract

Sumoylation is a covalent modification, which is mediated by small ubiquitin-like modifier (SUMO) polypeptides. A growing body of evidence has shown that sumoylation affects the functional properties of many substrates in the regulation of cellular processes. Recent reports indicate the crucial role of sumoylation in human diseases including familial dilated cardiomyopathy, suggesting that targeting of sumoylation would be of considerable interest for novel therapies. Even though hundreds of SUMO substrates have been identified, their pathophysiological roles remain to be determined. Among them, ERK5-sumoylation has recently been linked to diabetes and implicated in endothelial dysfunction and cardiomyocyte apoptosis in vivo. These findings support the idea that ERK5-sumoylation is a novel therapeutic target for the treatment of diabetes-related cardiovascular diseases.

  • References62
  • Citations15

References

  • References62
  • Citations15

Citations

Mentioned in this Paper

SUMO1 gene
Protein Desumoylation
Embryo
Establishment and Maintenance of Localization
Pathogenic Aspects
Biochemical Pathway
Area MI of Woolsey
Cyclic AMP-Responsive DNA-Binding Protein
Covalent Interaction
Conjugation

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