SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⁺ T cells in mice

Cellular Signalling
Tae Joon WonKwang Woo Hwang

Abstract

Small ubiquitin-like modifier (SUMO) 2 is a small protein that controls the activity and stability of other proteins by SUMOylation. In this study, T cell-specific SUMO2 overexpressing transgenic mice were generated to study the effect of SUMO2 on T lymphocytes. SUMO2 overexpression promoted differentiation of interleukin (IL)-17-producing CD8(+) T cells, and significantly suppressed the growth of EL4 tumor cells in vivo. Moreover, the tumor tissue from SUMO2-overexpressing mice had higher interferon (IFN)-γ and granzyme B mRNA levels. Although SUMO2 overexpression did not increase IFN-γ or granzyme B production in cytotoxic T lymphocytes, IL-12 treatment restored and increased IFN-γ secretion in IL-17-producing CD8(+) T cells. SUMO2 overexpression also increased gene expression of chemokines, CCL4, and CXCL10, which attract cytotoxic T lymphocytes to tumor tissues. Additionally, SUMO2-overexpressing T cells exhibited increased STAT3 phosphorylation, implying a SUMO2 target which up-regulates STAT3 activity governing IL-17A-producing CD8(+) T cell differentiation and antitumor immune responses.

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Citations

Oct 18, 2015·Neoplasia : an International Journal for Oncology Research·Deeksha VishwamitraHesham M Amin
Apr 14, 2016·Archives of Pharmacal Research·Yun-Jung LeeKwang Woo Hwang
Oct 19, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H-M Ivy YuWei Hsu
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Sajeev T KRam Kumar Mishra

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