SUMOylation and phosphorylation cross-talk in hepatocellular carcinoma

Translational Gastroenterology and Hepatology
Maria Lauda Tomasi, Komal Ramani

Abstract

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. The large spectrum of protein post-translational modification (PTM) includes numerous critical signaling events that occur during neoplastic transformation. PTMs occur to nearly all proteins and increase the functional diversity of proteins. We have reviewed the role of two major PTMs, SUMOylation and phosphorylation, in the altered signaling of key players in HCC. SUMOylation is a PTM that involves addition of a small ubiquitin-like modifiers (SUMO) group to proteins. It is known to regulate protein stability, protein-protein interactions, trafficking and transcriptional activity. The major pathways that are regulated by SUMOylation and may influence HCC are regulation of transcription, cell growth pathways associated with B-cell lymphoma 2 (Bcl-2) and methionine adenosyltransferases (MAT), oxidative stress pathways [nuclear erythroid 2-related factor 2 (Nrf2)], tumor suppressor pathways (p53), hypoxia-inducible signaling [hypoxia-inducible factor-1 (HIF-1)], glucose and lipid metabolism, nuclear factor kappa B (NF-κB) and β-Catenin signaling. Phosphorylation is an extens...Continue Reading

Citations

Jun 20, 2019·Electrophoresis·Zenghua ShengShufang Liang
Aug 13, 2020·International Journal of Molecular Sciences·Jianli HeTianshi Wang
Feb 4, 2021·Natural Products and Bioprospecting·Jean-François GoossensChristian Bailly
Oct 14, 2019·Archives of Biochemistry and Biophysics·Zheng WuLiang Yuan
May 27, 2021·Journal of Cellular Biochemistry·Ming-Cheng ChenChih-Yang Huang
Nov 13, 2018·Analytical Chemistry·Huiming YuanYukui Zhang

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