Sumoylation and phosphorylation: hidden and overt links

Journal of Experimental Botany
Konstantin TomanovAndreas Bachmair

Abstract

Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act interdependently to modulate stress responses. In particular, many components of the SUMO conjugation system are phosphoproteins, and some regulators and enzymes of protein phosphorylation can be sumoylated. Equally important, however, a number of proteins can be subject to both modifications. These substrates also have the capacity to connect stimuli transmitted via sumoylation with those transmitted via phosphorylation. As a prime example, we review data suggesting that nitrate reductase is a hub that integrates cues from these two modifications. Powerful proteomics approaches allowed the identification of additional common substrates, paving the way for studies to understand, on a broader basis, the cross-talk of phosphorylation with sumoylation and how it contributes to plant growth.

References

Oct 25, 2011·Nature·Daniel J GibbsMichael J Holdsworth

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Citations

Sep 1, 2018·Journal of Experimental Botany·Steven H Spoel
Mar 27, 2020·International Journal of Molecular Sciences·Tatiana ErazoJose M Lizcano
Aug 13, 2020·International Journal of Molecular Sciences·Jianli HeTianshi Wang
Dec 8, 2020·Frontiers in Physiology·Sumita MishraMark J Ranek
Apr 26, 2020·Seminars in Cell & Developmental Biology·Na LiCong-Yi Wang
Jun 3, 2021·Plants·Catherine M Doorly, Emmanuelle Graciet
Oct 7, 2021·The Plant Journal : for Cell and Molecular Biology·Caroline MercierThierry Desnos

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